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预测获得性胆脂瘤的复发:对当前分期系统的评估

Predicting Recidivism for Acquired Cholesteatoma: Evaluation of a Current Staging System.

作者信息

Angeli Simon, Shahal David, Brown Clifford Scott, Herman Bjorn

机构信息

Department of Otolaryngology, University of Miami, Miami, Florida.

出版信息

Otol Neurotol. 2020 Dec;41(10):1391-1396. doi: 10.1097/MAO.0000000000002823.

Abstract

OBJECTIVE

Assess the utility and prognostic capabilities of the European Academy of Otology and Neurotology (EAONO) and Japanese Otological Society (JOS) cholesteatoma classification system, specifically for retraction pocket cholesteatoma.

STUDY DESIGN

Retrospective.

SETTING

Tertiary referral hospital.

PATIENTS

Adults and children with retraction pocket cholesteatoma.

INTERVENTIONS

Primary and planned second-look tympanoplasty with mastoidectomy.

MAIN OUTCOME MEASURES

Incidence of recurrent or residual cholesteatoma at planned second-look surgery. Independent variables of age, gender, size of canal defect, and mucosa status were assessed. Additionally, the cholesteatoma classification, stage, and extent according to the EAONO/JOS system were recorded during the primary surgery.

RESULTS

A total of 125 cases were included. Twelve (9.6%) cases had recidivism over an average time of 7.5 months: the recurrence rate was 4% (n = 5), residual rate was 5% (n = 6), and one patient had both recurrent and residual disease (0.8%). Residual cholesteatoma occurred more frequently in children (p = 0.04, RR = 7.9 [1.0, 63.6]). Supratubal recess (S1) disease was associated with both recurrent cholesteatoma (p = 0.04, RR = 5.9 [1.3, 27.2]) and recidivism (p = 0.01, RR = 4.2 [1.5, 11.9]). Larger canal defects also showed an association with residual disease (p = 0.017).

CONCLUSION

Younger patients and those with large ear canal defects tend to have residual disease at second-look surgery. Supratubal recess disease is also associated with recurrence. Despite the utility of the EAONO/JOS classification and staging system for cholesteatoma description and type, the prognostic value remains uncertain.

摘要

目的

评估欧洲耳科学与神经耳科学学会(EAONO)和日本耳科学会(JOS)胆脂瘤分类系统的实用性和预后评估能力,特别是针对内陷袋型胆脂瘤。

研究设计

回顾性研究。

研究地点

三级转诊医院。

研究对象

患有内陷袋型胆脂瘤的成人和儿童。

干预措施

初次及计划中的二次探查鼓室成形术并联合乳突切除术。

主要观察指标

计划二次探查手术时复发性或残留性胆脂瘤的发生率。评估年龄、性别、耳道缺损大小和黏膜状态等自变量。此外,在初次手术时记录根据EAONO/JOS系统的胆脂瘤分类、分期和范围。

结果

共纳入125例病例。12例(9.6%)出现复发,平均复发时间为7.5个月:复发率为4%(n = 5),残留率为5%(n = 6),1例患者同时存在复发和残留疾病(0.8%)。残留胆脂瘤在儿童中更常见(p = 0.04,RR = 7.9 [1.0, 63.6])。上鼓室隐窝(S1)病变与复发性胆脂瘤(p = 0.04,RR = 5.9 [1.3, 27.2])和复发均相关(p = 0.01,RR = 4.2 [1.5, 11.9])。较大的耳道缺损也与残留疾病相关(p = 0.017)。

结论

年轻患者和耳道缺损较大的患者在二次探查手术时往往有残留疾病。上鼓室隐窝病变也与复发相关。尽管EAONO/JOS分类和分期系统在描述胆脂瘤及其类型方面有用,但预后价值仍不确定。

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