Durrer Manuela, Mevissen Meike, Holinger Mirjam, Hamburger Matthias, Graf-Schiller Sandra, Mayer Philipp, Potterat Olivier, Bruckmaier Rupert, Walkenhorst Michael
Department of Clinical Research and Veterinary Public Health, Division of Veterinary Pharmacology and Toxicology, Vetsuisse Faculty, University of Bern, Switzerland.
Department of Livestock Science, Research Institute of Organic Agriculture (FiBL), Frick, Switzerland.
Planta Med. 2020 Dec;86(18):1375-1388. doi: 10.1055/a-1260-3148. Epub 2020 Oct 1.
A blinded placebo-controlled multi-center on-farm trial was conducted in dairy cows with subclinical ketosis to investigate effects of a multicomponent herbal extract. Blood ketone levels were measured weekly in early lactating cows from 16 Swiss herds. Cows were subclassified based on their initial blood--hydroxybutyrate levels (≥ 1.0 [KET-low, 84 cows] and > 1.2 mmol/L [KET-high, 39 cows]) and randomly distributed to 3 groups treated orally with herbal extract containing , and , sodium propionate, or placebo twice a day for 5 days. Milk yield, milk acetone, blood--hydroxybutyrate, glucose, nonesterified fatty acids, gamma-glutamyl transferase, and glutamate dehydrogenase were analyzed over 2 wk. Linear mixed effect models were used for data analysis. No effects were found for nonesterifed fatty acids, gamma-glutamyl transferase, and glucose. Significantly higher glutamate dehydrogenase (29.71 U/L) values were found in herbal extract-treated animals compared to sodium propionate on day 7 (22.33 U/L). By trend, higher blood--hydroxybutyrate levels (1.36 mmol/L) were found in the placebo group of KET-high-cows on day 14 compared to the sodium propionate group (0.91 mmol/L). Milk yields of all treatment groups increased. Milking time and treatment showed a significant interaction for milk acetone: sodium propionate led to an immediate decrease, whereas herbal extracts resulted in a milk acetone decrease from day 7 on, reaching significantly lower milk acetone on day 14 (3.17 mg/L) when compared to placebo (4.89 mg/L). In conclusion, herbal extracts and sodium propionate are both likely to improve subclinical ketosis in dairy cows, however, by different modes of action.
在患有亚临床酮病的奶牛中进行了一项双盲、安慰剂对照的多中心农场试验，以研究一种多成分草药提取物的效果。每周对来自16个瑞士牛群的初产奶牛的血酮水平进行测量。根据奶牛最初的血β-羟基丁酸水平（≥1.0[低酮血症，84头奶牛]和>1.2 mmol/L[高酮血症，39头奶牛]）进行亚分类，并随机分为3组，每天口服含、和丙酸钠的草药提取物或安慰剂，持续5天。在2周内分析了产奶量、乳丙酮、血β-羟基丁酸、葡萄糖、非酯化脂肪酸、γ-谷氨酰转移酶和谷氨酸脱氢酶。使用线性混合效应模型进行数据分析。未发现非酯化脂肪酸、γ-谷氨酰转移酶和葡萄糖有影响。与丙酸钠组（22.33 U/L）相比，在第7天，草药提取物处理的动物中谷氨酸脱氢酶值显著更高（29.71 U/L）。趋势上，在第14天，高酮血症奶牛的安慰剂组血β-羟基丁酸水平（1.36 mmol/L）高于丙酸钠组（0.91 mmol/L）。所有治疗组的产奶量均增加。挤奶时间和治疗对乳丙酮有显著交互作用：丙酸钠导致立即下降，而草药提取物从第7天开始导致乳丙酮下降，与安慰剂组（4.89 mg/L）相比，在第14天乳丙酮显著更低（3.17 mg/L）。总之，草药提取物和丙酸钠都可能改善奶牛的亚临床酮病，然而，作用方式不同。
