Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093-0995, USA.
Int J Environ Res Public Health. 2020 Sep 29;17(19):7136. doi: 10.3390/ijerph17197136.
Most people have no problems when administered vaccines; however, as with all drugs, reported adverse effects (rAEs) do occur. There is a need to better understand the potential predictors of reported vaccine AEs (rVaxAEs), including modifiable (environmental) predictors. Gulf War Veterans (GWV) who have Gulf War illness (GWI) report increased experiences of drug and chemical rAEs, extending to rVaxAEs. GWV provide an opportunity to examine the relationship between their reported exposures and rAEs. Forty one GWV with GWI and 40 healthy controls reported exposure and rAEs to exposure, including for 14 vaccines. Individual and summed vaccine exposures, rVaxAEs, and reported Vaccine AE Propensity (summed rVaxAEs/summed vaccines exposures) were compared in cases vs. controls. Exposure-outcome assessments focused on GWV, using a multivariable regression with robust standard error. More designated vaccines were reported in cases than in controls: 9.0 (2.3) vs. 3.8 (2.3), < 0.0001. The fraction of vaccines received that led to rAEs was ten-fold higher in cases: 0.24 (0.21), vs. 0.023 (0.081), < 0.0001. Multivariable assessment confirmed that radiation and pesticides remained significant statistical predictors of reported Vaccine AE Propensity. Exposure tied to excess rVaxAEs in GWV may contribute to, or underlie, the reported link between rVaxAEs in GWV and later ill health.
大多数人在接种疫苗时没有问题；然而，与所有药物一样，报告的不良反应（rAEs）确实会发生。需要更好地了解报告的疫苗不良反应（rVaxAEs）的潜在预测因素，包括可改变的（环境）预测因素。患有海湾战争病（GWI）的海湾战争退伍军人（GWV）报告说，药物和化学 rAEs 的经历增加，包括 rVaxAEs。GWV 为研究他们报告的暴露与 rAEs 之间的关系提供了机会。41 名患有 GWI 的 GWV 和 40 名健康对照者报告了暴露和 rAEs 情况，包括 14 种疫苗。在病例与对照组中，比较了个体和总和疫苗暴露、rVaxAEs 和报告的疫苗 AE 倾向（总和 rVaxAEs/总和疫苗暴露）。使用稳健标准误差的多变量回归对 GWV 进行了暴露-结果评估。病例组报告的指定疫苗数量多于对照组：9.0（2.3）比 3.8（2.3），<0.0001。病例组因 rAEs 而导致的疫苗接种比例高出十倍：0.24（0.21），比 0.023（0.081），<0.0001。多变量评估证实，辐射和农药仍然是报告的疫苗 AE 倾向的重要统计预测因素。GWV 中与过量 rVaxAEs 相关的暴露可能导致或构成 GWV 中 rVaxAEs 与后来健康不良之间的报告联系。
