Irshad Muhammad, Alam Mohammad Khursheed, Alawneh Ahmad, Alhadi Mohammed Abdullah, Alhadi Ahmed Abdullah, Almunajem Yasser Saleh, Alanezi Fesal Farag, Al Sagoor Sharafi Abdullah, Bajawi Abdulrahman Mudaysh, Alfawzan Ahmed Ali, Kamal Mohammad Amjad
Department of Oral Pathology, Rehman College of Dentistry, RMI, Hayatabad Phase V, Peshawar, KP, Peshawar 25000, Pakistan.
College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia.
Antibiotics (Basel). 2020 Sep 29;9(10):654. doi: 10.3390/antibiotics9100654.
Knowledge of microbial composition and antimicrobials' susceptibility to periodontal abscesses is vital for their successful treatment. The current study aims to provide a thorough overview of the clinical and microbial features of periodontal abscesses of the local community. The study was carried out at Rehman College of Dentistry, Peshawar, Pakistan between December 2019 to March 2020. Clinical measurements and microbial samples were collected from 45 subjects. Microbial samples were anaerobically cultured for the growth of selected bacterial species. E-test was used to assess the susceptibility of bacterial species grown from the patient samples to amoxicillin, azithromycin, metronidazole, and tetracycline. The majority of affected patients had preexisting chronic periodontitis. All abscesses clinically demonstrated bleeding on probing and suppuration. The periodontal abscess was most commonly associated with lower incisors and canines, followed by lower molars and then upper incisor and canine teeth. spp. (73%) was the most frequently detected species followed by (65%), (46%) and (24%). The detected clinical isolates of certain bacteria demonstrated resistance to all tested antibiotics except azithromycin. We conclude that spp., , and are closely associated with periodontal abscess. Bacterial species associated with periodontal abscess demonstrated some level of antimicrobial resistance to amoxicillin, metronidazole and tetracycline while antibiotic resistance to azithromycin could not be demonstrated.
了解微生物组成以及抗菌药物对牙周脓肿的敏感性对于其成功治疗至关重要。本研究旨在全面概述当地社区牙周脓肿的临床和微生物特征。该研究于2019年12月至2020年3月在巴基斯坦白沙瓦的雷曼牙科学院进行。从45名受试者中收集了临床测量数据和微生物样本。对微生物样本进行厌氧培养以培养选定的细菌种类。采用E-test评估从患者样本中培养出的细菌种类对阿莫西林、阿奇霉素、甲硝唑和四环素的敏感性。大多数受影响患者先前患有慢性牙周炎。所有脓肿在临床检查时均表现为探诊出血和化脓。牙周脓肿最常与下切牙和尖牙相关，其次是下磨牙，然后是上切牙和尖牙。spp.（73%）是最常检测到的菌种，其次是（65%）、（46%）和（24%）。检测到的某些细菌临床分离株对除阿奇霉素外的所有测试抗生素均表现出耐药性。我们得出结论，spp.、、和与牙周脓肿密切相关。与牙周脓肿相关的细菌种类对阿莫西林、甲硝唑和四环素表现出一定程度的抗菌耐药性，而对阿奇霉素未表现出耐药性。
