Guzman Frederick, Fazeli Yasamin, Khuu Meagan, Salcido Kelsey, Singh Sarah, Benavente Claudia A
Department of Pharmaceutical Sciences, University of California, 101 Theory #100, Irvine, CA 92617, USA.
School of Biological Sciences, University of California, 5120 Natural Sciences II, Irvine, CA 92697, USA.
Cancers (Basel). 2020 Sep 29;12(10):2807. doi: 10.3390/cancers12102807.
Mutations that result in the loss of function of pRB were first identified in retinoblastoma and since then have been associated with the propagation of various forms of cancer. pRB is best known for its key role as a transcriptional regulator during cell cycle exit. Beyond the ability of pRB to regulate transcription of cell cycle progression genes, pRB can remodel chromatin to exert several of its other biological roles. In this review, we discuss the diverse functions of pRB in epigenetic regulation including nucleosome mobilization, histone modifications, DNA methylation and non-coding RNAs.
导致视网膜母细胞瘤蛋白（pRB）功能丧失的突变最初是在视网膜母细胞瘤中发现的，从那时起，它就与各种癌症的发生发展相关联。pRB最为人所知的是其在细胞周期退出过程中作为转录调节因子的关键作用。除了pRB调节细胞周期进程基因转录的能力外，pRB还可以重塑染色质以发挥其其他多种生物学作用。在这篇综述中，我们讨论了pRB在表观遗传调控中的多种功能，包括核小体移动、组蛋白修饰、DNA甲基化和非编码RNA。
