Gillum D M, Falk S A, Hammond W S, Conger J D
Am J Physiol. 1987 Jul;253(1 Pt 2):F170-9. doi: 10.1152/ajprenal.1987.253.1.F170.
Munich-Wistar rats underwent thyroidectomy (TX) with reimplantation of the parathyroid glands. Systemic hemodynamic and micropuncture studies were performed at 1 and 3 wk post-TX, and the results were compared with levothyroxine replaced controls (TXT4). Cardiac output (CO) in TX rats fell progressively and was 40% of that in TXT4 at 3 wk. Renal blood flow declined in parallel with CO. Systemic blood pressure did not fall in TX rats because of a 50% increase in systemic vascular resistance by 3 wk post-TX. Glomerular dynamics were not significantly different between TX and TXT4 rats at 1 wk; however, by 3 wk single-nephron glomerular filtration rate (SNGFR) had fallen to 16.5 +/- 1.1 vs. 34.1 +/- 3.4 nl/min in TXT4 controls (P less than 0.001). In 3-wk TX rats, glomerular plasma flow (QA) was 50.9 +/- 3.7 vs. 108.0 +/- 8.7 nl/min in TXT4 rats (P less than 0.001), net hydraulic ultrafiltration pressure (delta P) was 33 +/- 2 vs. 37 +/- 1 mmHg in TXT4 rats (P less than 0.01), and the ultrafiltration coefficient (Kf) was 0.025 +/- 0.003 vs. 0.084 +/- 0.008 nl X s-1 X mmHg-1 in TXT4 controls (P less than 0.001). Although the changes in systemic and glomerular hemodynamics were progressive over 3 wk, proximal tubular reabsorption fell maximally within 1 wk. Similar patterns of alterations in glomerular dynamics are known physiological consequences of angiotensin II (ANG II).(ABSTRACT TRUNCATED AT 250 WORDS)
慕尼黑-威斯塔大鼠接受甲状腺切除术（TX）并同时进行甲状旁腺再植。在TX术后1周和3周进行全身血流动力学和微穿刺研究，并将结果与左甲状腺素替代对照组（TXT4）进行比较。TX大鼠的心输出量（CO）逐渐下降，在3周时为TXT4组的40%。肾血流量与CO平行下降。TX大鼠的全身血压没有下降，因为在TX术后3周全身血管阻力增加了50%。在1周时，TX大鼠和TXT4大鼠的肾小球动力学没有显著差异；然而，到3周时，单肾单位肾小球滤过率（SNGFR）降至16.5±1.1 nl/min，而TXT4对照组为34.1±3.4 nl/min（P<0.001）。在3周龄的TX大鼠中，肾小球血浆流量（QA）为50.9±3.7 nl/min，而TXT4大鼠为108.0±8.7 nl/min（P<0.001），净水力超滤压力（ΔP）为33±2 mmHg，而TXT4大鼠为37±1 mmHg（P<0.01），超滤系数（Kf）为0.025±0.003 nl·s-1·mmHg-1，而TXT4对照组为0.084±0.008 nl·s-1·mmHg-1（P<0.001）。尽管全身和肾小球血流动力学变化在3周内是渐进的，但近端肾小管重吸收在1周内最大程度下降。肾小球动力学的类似变化模式是已知的血管紧张素II（ANG II）的生理后果。（摘要截断于250字）
