Bradley S E, Coelho J B, Sealey J E, Edwards K D, Stéphan F
Life Sci. 1982;30(7-8):633-9. doi: 10.1016/0024-3205(82)90279-x.
Glomerular diameters (GD) and lengths of attached proximal convoluted tubules (TPL) were measured in nephrons dissected from the superficial (S), intermediate and juxtamedullary (JM) cortex (7-15 each) of acid-macerated kidneys of weight-matched (E) euthyroid and (H) hypothyroid (2-6 months after radioiodine treatment or thyroidectomy) male Sherman-Wistar rats. Incoordination of growth in H rats was evident in a more marked retardation in kidney than in total body growth. A similar incoordination of microstructural growth was evident in maintenance or GD within normal limits with respect to body weight while attached TPL fell 23% on the average below control values relative to body weight. These changes affected the total nephron population uniformly. As a result, GD/TPL in all nephrons increased significantly (p less than 0.01), by 27% in S and by 29% in JM nephrons. The glomerulotubular dimensional imbalance was associated with a marked and uniformly distributed reduction in single nephron glomerular filtration rate (ferrocyanide method), by 36% in S and JM nephrons. Plasma renin activity fell within normal limits while plasma renin substrate was decreased to 56% of control values. These findings are construed as evidence that growth retardation in hypothyroid rats affects the parenchyma of the kidney (and perhaps other viscera) more than the vasculature.
在体重匹配的正常甲状腺（E）和甲状腺功能减退（H）（放射性碘治疗或甲状腺切除术后2 - 6个月）雄性谢尔曼 - 威斯塔大鼠的酸浸软肾中，测量从浅表（S）、中间和近髓质（JM）皮质解剖出的肾单位的肾小球直径（GD）和附着的近端曲管长度（TPL）（每组7 - 15个）。甲状腺功能减退大鼠的生长不协调表现为肾脏生长比全身生长更明显迟缓。微观结构生长的类似不协调表现为，相对于体重，肾小球直径维持在正常范围内，而附着的近端曲管平均比对照值低23%。这些变化对整个肾单位群体产生了均匀影响。结果，所有肾单位的GD/TPL显著增加（p < 0.01），浅表肾单位增加27%，近髓质肾单位增加29%。肾小球 - 肾小管尺寸失衡与单个肾单位肾小球滤过率显著且均匀分布的降低相关（亚铁氰化物法），浅表和近髓质肾单位降低36%。血浆肾素活性保持在正常范围内，而血浆肾素底物降至对照值的56%。这些发现被解释为甲状腺功能减退大鼠生长迟缓对肾脏实质（可能还有其他内脏）的影响大于对脉管系统的影响的证据。
