白血病细胞起源解释的治疗反应和结果。
Therapy Response and Outcome Explained by Leukemia Cell of Origin.
机构信息
Children's Medical Center Research Institute, Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas.
出版信息
Cancer Discov. 2020 Oct;10(10):1445-1447. doi: 10.1158/2159-8290.CD-20-1080.
In this issue of , Cai and colleagues delineate a new mechanism that links cell of origin, the transcription factor EVI1, apoptotic priming, and therapeutic susceptibility in mixed lineage leukemia-rearranged acute myeloid leukemia. These findings establish a cell of origin-dependent program that may be leveraged by therapeutic combinations to overcome drug resistance in chemoresistant leukemias..
在本期的 中，蔡和他的同事们描绘了一个新的机制，该机制将起始细胞、转录因子 EVI1、凋亡启动和治疗敏感性联系起来，用于治疗混合谱系白血病重排的急性髓系白血病。这些发现建立了一个依赖于起始细胞的程序，可能被治疗组合利用，以克服耐药性白血病中的耐药性。
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