Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China.
Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, China.
Mediators Inflamm. 2020 Sep 12;2020:2076328. doi: 10.1155/2020/2076328. eCollection 2020.
Pain is the most common symptom in patients with rheumatoid arthritis (RA). Although in recent years, through the implementation of targeted treatment and the introduction of disease-modifying antirheumatic drugs (DMARDs), the treatment of RA patients has made a significant progress, a large proportion of patients still feel pain. Finding appropriate treatment to alleviate the pain is very important for RA patients. Current research showed that, in addition to inflammation, RA pain involves peripheral sensitization and abnormalities in the central nervous system (CNS) pain regulatory mechanisms. This review summarized the literature on pain mechanisms of RA published in recent years. A better understanding of pain mechanisms will help to develop new analgesic targets and deploy new and existing therapies.
疼痛是类风湿关节炎（RA）患者最常见的症状。尽管近年来，通过实施靶向治疗和引入改善病情抗风湿药（DMARDs），RA 患者的治疗取得了重大进展，但仍有很大一部分患者感到疼痛。寻找合适的治疗方法来缓解疼痛对 RA 患者非常重要。目前的研究表明，除了炎症之外，RA 疼痛还涉及外周敏化和中枢神经系统（CNS）疼痛调节机制的异常。本文综述了近年来发表的关于 RA 疼痛机制的文献。更好地了解疼痛机制将有助于开发新的镇痛靶点，并部署新的和现有的治疗方法。
