Association Between Interictal High-Frequency Oscillations and Slow Wave in Refractory Focal Epilepsy With Good Surgical Outcome.

High-frequency oscillations (HFOs) have been proposed as a promising biomarker of the epileptogenic zone (EZ). But accurate delineation of EZ based on HFOs is still challenging. Our study compared HFOs from EZ and non-EZ on the basis of their associations with interictal slow waves, aiming at exploring a new way to localize EZ. Nineteen medically intractable epilepsy patients with good surgical outcome were included. Five minute interictal intracranial electroencephalography (EEG) epochs of slow-wave sleep were randomly selected; then ripples (80-200 Hz), fast ripples (FRs; 200-500 Hz), and slow waves (0.1-4 Hz) were automatically analyzed. The EZ and non-EZ were identified by resection range during the surgeries. We found that both ripples and FRs superimposed more frequently on slow waves in EZ than in non-EZ ( < 0.01). Although ripples preferred to occur on the down state of slow waves in both two groups, ripples in EZ tended to be closer to the down-state peak of slow wave than in non-EZ (-174 vs. -231 ms, = 0.008). As for FR, no statistical difference was found between the two groups ( = 0.430). Additionally, slow wave-containing ripples in EZ had a steeper slope (1.7 vs. 1.5 μV/ms, < 0.001) and wider distribution ratio (32.3 vs. 30.1%, < 0.001) than those in the non-EZ. But for slow wave-containing FR, only a steeper slope (1.7 vs. 1.4 μV/ms, < 0.001) was observed. Our study innovatively compared the different features of association between HFOs and slow wave in EZ and non-EZ from refractory focal epilepsy with good surgical outcome, proposing a new method to localize EZ and facilitating the surgical plan.