Kim Yong-Soon, Cho Eun-Sang, Park Ka-Young, Lim Cheol-Hong
Chemical Research Bureau, Occupational Safety and Health Research Institute, KOSHA, Daejeon, 34122 Republic of Korea.
Toxicol Res. 2020 Jan 20;36(4):285-292. doi: 10.1007/s43188-019-00033-1. eCollection 2020 Oct.
1-Propanol is used as a solvent for waxes, vegetable oils, resins, cellulose esters, and ethers, and is not considered harmful to humans by food and non-occupational exposures. However, workers are potentially exposed to 1-propanol by inhalation when it is used in the workplace. Thus, inhalation toxicity data are needed to assess the hazard of 1-propanol for workers safety. Five male and five female F344 rats were exposed to 1-propanol vapor for 4-weeks (6 h/day, 5 days/week) at concentrations of 0, 100, 400, and 1600 ppm in a whole-body inhalation chamber system. The actual exposure concentrations were 100.11 ± 5.10, 403.19 ± 12.31, and 1598.08 ± 139.58 ppm for the low, middle, and high dose groups, respectively. No clinical signs, significant mean body weight changes, significant changes of hematology or blood biochemistry results, or histopathological abnormalities were seen related to exposure to the test substance. Under the conditions of this study, the no-observed-adverse-effect level of 1-propanol was over 1600 ppm.
1-丙醇用作蜡、植物油、树脂、纤维素酯和醚的溶剂，食品和非职业接触情况下不认为其对人体有害。然而，在工作场所使用时，工人有可能通过吸入接触1-丙醇。因此，需要吸入毒性数据来评估1-丙醇对工人安全的危害。将5只雄性和5只雌性F344大鼠置于全身吸入舱系统中，以0、100、400和1600 ppm的浓度暴露于1-丙醇蒸气中4周（每天6小时，每周5天）。低、中、高剂量组的实际暴露浓度分别为100.11±5.10、403.19±12.31和1598.08±139.58 ppm。未观察到与受试物接触相关的临床症状、平均体重显著变化、血液学或血液生化结果的显著变化或组织病理学异常。在本研究条件下，1-丙醇的未观察到有害作用水平超过1600 ppm。
