Kim Yong-Soon, Park Ka-Young, Cho Eun-Sang
Chemical Research Bureau, Occupational Safety and Health Research Institute, KOSHA, Daejeon 34122, Republic of Korea.
Toxicol Rep. 2021 Nov 6;8:1839-1845. doi: 10.1016/j.toxrep.2021.11.004. eCollection 2021.
1-Propanol is a colorless volatile liquid at room temperature and is an important industrial alcohol. Workers are potentially exposed to it through inhalation during industrial activities, including manufacturing, sampling, filling, and mixing processes, as well as during cleaning, maintenance, and repair. Consequently, further information and/or testing for inhalation-related toxicological data is required to assess occupational risk. In this study, 80 (40 male and 40 female) F344 rats were exposed to 1-propanol vapors for 13 weeks (6 h a day, 5 days per week) at target concentrations of 0, 500, 1,600, and 5200 ppm in a whole-body inhalation chamber system. Clinical signs, mean body weight changes, food consumption, hematology, blood biochemistry, necropsy, organ weight, and histopathological findings were observed. The exposure concentrations in chambers were 501.30 ± 9.54 ppm, 1605.43 ± 66.55 ppm, and 5202.19 ± 102.74 ppm for the low, middle, and high dose groups, respectively. No changes related to 1-propanol were observed, including histopathological findings, except for mean body weight changes. The significant decrease in mean body weight at a high dose was not considered to be an adverse effect. Based on these results, the no observed adverse effect concentration of 1-propanol was estimated to be 5202.19 ppm.
1-丙醇在室温下是一种无色挥发性液体，是一种重要的工业酒精。在包括制造、采样、灌装和混合过程，以及清洁、维护和修理等工业活动中，工人有可能通过吸入接触到它。因此，需要进一步的信息和/或吸入相关毒理学数据测试来评估职业风险。在本研究中，80只（40只雄性和40只雌性）F344大鼠在全身吸入舱系统中，以0、500、1600和5200 ppm的目标浓度暴露于1-丙醇蒸气中13周（每天6小时，每周5天）。观察临床症状、平均体重变化、食物消耗、血液学、血液生化、尸检、器官重量和组织病理学结果。低、中、高剂量组舱内的暴露浓度分别为501.30±9.54 ppm、1605.43±66.55 ppm和5202.19±102.74 ppm。除平均体重变化外，未观察到与1-丙醇相关的变化，包括组织病理学结果。高剂量组平均体重的显著下降不被认为是一种不良反应。基于这些结果，估计1-丙醇的未观察到不良反应浓度为5202.19 ppm。
