从头孢曲松转换为头孢噻肟对减轻感染负担有显著作用。
Switching From Ceftriaxone to Cefotaxime Significantly Contributes to Reducing the Burden of infections.
作者信息
Wendt Sebastian, Ranft Donald, Rodloff Arne C, Lippmann Norman, Lübbert Christoph
机构信息
Division of Infectious Diseases and Tropical Medicine, Department of Medicine II, Leipzig University Hospital, Leipzig, Germany.
Institute for Medical Microbiology and Epidemiology of Infectious Diseases, Leipzig University Hospital, Leipzig, Germany.
出版信息
Open Forum Infect Dis. 2020 Aug 23;7(9):ofaa312. doi: 10.1093/ofid/ofaa312. eCollection 2020 Sep.
Abstract
We analyzed infection (CDI) rates and various antimicrobials' application densities from 2013 to 2019 at Leipzig University Hospital, Germany, by using multivariate linear regression. Ceftriaxone application was the only independent predictor of CDI incidence. Thus, antibiotics' specific pharmacokinetic and pharmacodynamic properties such as biliary excretion of ceftriaxone in its active form should be considered when determining their potential to cause CDI.
摘要
我们运用多元线性回归分析了2013年至2019年德国莱比锡大学医院的感染（艰难梭菌感染）率和各种抗菌药物的应用密度。头孢曲松的应用是艰难梭菌感染发生率的唯一独立预测因素。因此，在确定抗生素导致艰难梭菌感染的可能性时，应考虑其特定的药代动力学和药效学特性，如头孢曲松以活性形式经胆汁排泄的情况。
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