Liu Elaine, Prinzi Andrea M, Borjan Jovan, Aitken Samuel L, Bradford Patricia A, Wright William F
Division of Pharmacy and Division of Infectious Diseases, The Johns Hopkins Bayview Medical Center, 5200 Eastern Avenue, Baltimore, MD, USA.
US Medical Affairs, bioMérieux, Salt Lake City, UT 84104, USA.
JAC Antimicrob Resist. 2023 Aug 14;5(4):dlad097. doi: 10.1093/jacamr/dlad097. eCollection 2023 Aug.
Antimicrobial resistance (AMR) continues to serve as a major global health crisis. Clinicians practising in this modern era are faced with ongoing challenges in the therapeutic management of patients suffering from antimicrobial-resistant infections. A strong educational understanding and synergistic application of clinical microbiology, infectious disease and pharmacological concepts can assist the adventuring clinician in the navigation of such cases. Important items include mobilizing laboratory testing for pathogen identification and susceptibility data, harnessing an understanding of intrinsic pathogen resistance, acknowledging epidemiological resistance trends, recognizing acquired AMR mechanisms, and consolidating these considerations when constructing an ideal pharmacological plan. In this article, we outline a novel framework by which to systematically approach clinical AMR, encourage AMR-related education and optimize therapeutic decision-making in AMR-related illnesses.
抗菌药物耐药性(AMR)仍然是一个重大的全球健康危机。在这个现代时代执业的临床医生在治疗耐抗菌药物感染的患者时面临着持续的挑战。对临床微生物学、传染病学和药理学概念有深入的教育理解并进行协同应用,可以帮助有探索精神的临床医生处理此类病例。重要的事项包括推动实验室检测以获取病原体鉴定和药敏数据,了解病原体的固有耐药性,认识流行病学耐药趋势,识别获得性AMR机制,以及在制定理想的药理学方案时综合考虑这些因素。在本文中,我们概述了一个系统处理临床AMR的新框架,鼓励开展与AMR相关的教育,并优化AMR相关疾病的治疗决策。