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克罗恩病复发的预防:外科医生的观点

Prophylaxis of Crohn's disease recurrence: A surgeon's perspective.

作者信息

Wolford Dallas D, Fichera Alessandro

机构信息

Division of Colorectal Surgery Department of Surgery Baylor University Medical Center Dallas Texas USA.

出版信息

Ann Gastroenterol Surg. 2020 Jun 24;4(5):514-520. doi: 10.1002/ags3.12368. eCollection 2020 Sep.

DOI:10.1002/ags3.12368
PMID:33005846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7511563/
Abstract

Management of inflammatory bowel disease has evolved extensively in the last three decades. We have learnt a lot about the pathophysiology and natural history of the disease. New effective classes of drugs with the associated potential morbidity have been introduced. New surgical techniques have been popularized leading to a better understanding of the optimal timing of surgery. The result is a very complex subspecialty of gastroenterology and colorectal surgery called the "IBDologist." Only if we manage these complex patients in the context of a multi-disciplinary team will we be able to obtain outstanding outcomes, specifically with high and sustained remission rates for these patients.

摘要

在过去三十年中,炎症性肠病的管理发生了广泛演变。我们对该疾病的病理生理学和自然史有了很多了解。引入了具有相关潜在发病率的新型有效药物类别。新的外科技术得到普及,从而使人们对手术的最佳时机有了更好的理解。结果形成了胃肠病学和结直肠外科中一个非常复杂的亚专业,即“炎症性肠病专家”。只有在多学科团队的背景下管理这些复杂患者,我们才能取得出色的治疗效果,特别是使这些患者获得高且持续的缓解率。

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1
Prophylaxis of Crohn's disease recurrence: A surgeon's perspective.克罗恩病复发的预防:外科医生的观点
Ann Gastroenterol Surg. 2020 Jun 24;4(5):514-520. doi: 10.1002/ags3.12368. eCollection 2020 Sep.
2
Visceral adiposity and inflammatory bowel disease.内脏肥胖与炎症性肠病。
Int J Colorectal Dis. 2021 Nov;36(11):2305-2319. doi: 10.1007/s00384-021-03968-w. Epub 2021 Jun 9.
3
[The Kono-S anastomosis in surgery for Crohn's disease : First results of a new functional end-to-end anastomotic technique after intestinal resection in patients with Crohn's disease in Germany].[克罗恩病手术中的科诺-斯吻合术:德国克罗恩病患者肠道切除术后一种新型功能性端端吻合技术的初步结果]
Chirurg. 2019 Feb;90(2):131-136. doi: 10.1007/s00104-018-0668-4.
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Major Abdominal and Perianal Surgery in Crohn's Disease: Long-term Follow-up of Australian Patients With Crohn's Disease.克罗恩病的腹部和肛周大手术:澳大利亚克罗恩病患者的长期随访
Dis Colon Rectum. 2018 Jan;61(1):67-76. doi: 10.1097/DCR.0000000000000975.
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Surgical recurrence in Crohn's disease: a comparison between different types of bowel resections.克罗恩病的手术复发:不同类型肠切除术的比较。
Int J Colorectal Dis. 2018 Apr;33(4):473-477. doi: 10.1007/s00384-018-2995-9. Epub 2018 Feb 28.
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Small Bowel Crohn's Disease Recurrence is Common After Total Proctocolectomy for Crohn's Colitis.全结肠直肠切除术后回肠克罗恩病复发在克罗恩结肠炎中很常见。
Dis Colon Rectum. 2022 Mar 1;65(3):390-398. doi: 10.1097/DCR.0000000000002328.
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Long-term results of ileal pouch-anal anastomosis for colorectal Crohn's disease.结直肠克罗恩病回肠贮袋肛管吻合术的长期结果
Dis Colon Rectum. 2001 Jun;44(6):769-78. doi: 10.1007/BF02234693.
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Factors affecting recurrence after surgery for Crohn's disease.影响克罗恩病手术后复发的因素。
World J Gastroenterol. 2005 Jul 14;11(26):3971-9. doi: 10.3748/wjg.v11.i26.3971.
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The Portsmouth protocol for intra-operative ultrasound of the small bowel in Crohn's disease.《克罗恩病术中小肠超声的朴茨茅斯议定书》。
Colorectal Dis. 2020 Mar;22(3):342-345. doi: 10.1111/codi.14888. Epub 2019 Nov 17.
10
Surgical therapy for Crohn's disease.克罗恩病的手术治疗
Gastroenterol Clin North Am. 1989 Mar;18(1):111-28.

引用本文的文献

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Is Deep Remission the Right Time to De-Escalate Biologic Therapy in IBD? A Single-Center Retrospective Study.深度缓解是IBD中降低生物治疗强度的合适时机吗?一项单中心回顾性研究。
Biomedicines. 2025 Aug 7;13(8):1928. doi: 10.3390/biomedicines13081928.
2
Kono-S anastomosis in Crohn's disease: initial experience in pediatric patients.克罗恩病的 Kono-S 吻合术:小儿患者的初步经验。
Pediatr Surg Int. 2024 Mar 5;40(1):67. doi: 10.1007/s00383-024-05648-6.
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Impact of myopenia and myosteatosis on postoperative outcome and recurrence in Crohn's disease.肌肉减少症和肌内脂肪浸润对克罗恩病术后结局和复发的影响。
Int J Colorectal Dis. 2022 Apr;37(4):791-804. doi: 10.1007/s00384-022-04104-y. Epub 2022 Feb 14.
4
Cholinergic immunomodulation in inflammatory bowel diseases.炎症性肠病中的胆碱能免疫调节
Brain Behav Immun Health. 2021 Dec 11;19:100401. doi: 10.1016/j.bbih.2021.100401. eCollection 2022 Feb.
5
Endoscopic Features of Postoperative Anastomotic Lesions in Patients with Crohn's Disease Compared with Right-side Colon Cancer: Are Anastomotic Linear Superficial Ulcers Recurrent in Crohn's Disease?克罗恩病患者术后吻合口病变与右侧结肠癌的内镜特征比较:克罗恩病中的吻合口线性浅表溃疡会复发吗?
J Anus Rectum Colon. 2021 Apr 28;5(2):158-166. doi: 10.23922/jarc.2020-088. eCollection 2021.

本文引用的文献

1
Development of a prognostic model for one-year surgery risk in Crohn's disease patients: A retrospective study.克罗恩病患者一年内手术风险的预后模型的建立:一项回顾性研究。
World J Gastroenterol. 2020 Feb 7;26(5):524-534. doi: 10.3748/wjg.v26.i5.524.
2
Stapled versus handsewn methods for ileocolic anastomoses.吻合器吻合与手工缝合在回肠结肠吻合术中的比较。
Tech Coloproctol. 2019 Nov;23(11):1093-1095. doi: 10.1007/s10151-019-02105-8. Epub 2019 Nov 15.
3
Rate of Reoperation Decreased Significantly After Year 2002 in Patients With Crohn's Disease.2002年后,克罗恩病患者再次手术率显著下降。
Clin Gastroenterol Hepatol. 2020 Apr;18(4):898-907.e5. doi: 10.1016/j.cgh.2019.07.025. Epub 2019 Jul 20.
4
Estimated prevalence of ulcerative colitis and Crohn's disease in Japan in 2014: an analysis of a nationwide survey.2014 年日本溃疡性结肠炎和克罗恩病的预估患病率:一项全国性调查分析。
J Gastroenterol. 2019 Dec;54(12):1070-1077. doi: 10.1007/s00535-019-01603-8. Epub 2019 Jul 15.
5
Surgical Recurrence at Anastomotic Site After Bowel Resection in Crohn's Disease: Comparison of Kono-S and End-to-end Anastomosis.克罗恩病肠切除术后吻合口再手术:近侧-侧吻合与端端吻合的比较。
J Gastrointest Surg. 2019 Feb;23(2):312-319. doi: 10.1007/s11605-018-4012-6. Epub 2018 Oct 23.
6
Stapled side-to-side anastomosis might be benefit in intestinal resection for Crohn's disease: A systematic review and network meta-analysis.吻合器侧侧吻合术可能对克罗恩病肠切除术有益:一项系统评价与网状Meta分析
Medicine (Baltimore). 2018 Apr;97(15):e0315. doi: 10.1097/MD.0000000000010315.
7
Inclusion of the Mesentery in Ileocolic Resection for Crohn's Disease is Associated With Reduced Surgical Recurrence.回肠结肠切除术时包含肠系膜可降低克罗恩病的手术复发率。
J Crohns Colitis. 2018 Nov 9;12(10):1139-1150. doi: 10.1093/ecco-jcc/jjx187.
8
Smoking influences the need for surgery in patients with the inflammatory bowel diseases: a systematic review and meta-analysis incorporating disease duration.吸烟对炎症性肠病患者手术需求的影响:一项纳入疾病持续时间的系统评价和荟萃分析。
BMC Gastroenterol. 2016 Dec 21;16(1):143. doi: 10.1186/s12876-016-0555-8.
9
Microbial Factors Associated with Postoperative Crohn's Disease Recurrence.与术后克罗恩病复发相关的微生物因素。
J Crohns Colitis. 2017 Feb;11(2):191-203. doi: 10.1093/ecco-jcc/jjw136. Epub 2016 Jul 27.
10
Infliximab Reduces Endoscopic, but Not Clinical, Recurrence of Crohn's Disease After Ileocolonic Resection.英夫利昔单抗可降低回结肠切除术后克罗恩病的内镜复发率,但不能降低临床复发率。
Gastroenterology. 2016 Jun;150(7):1568-1578. doi: 10.1053/j.gastro.2016.02.072. Epub 2016 Mar 3.