Microbial Biotechnology Laboratory, Department of Marine Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620 024, India.
Department of Medical Microbiology, College of Health and Medical Sciences, Haramaya University, P.O. Box 235, Harar, Ethiopia.
Environ Sci Pollut Res Int. 2020 Dec;27(36):44922-44936. doi: 10.1007/s11356-020-10989-5. Epub 2020 Oct 1.
Biofilm, a consortium of microbial cells, protected by extracellular polymeric matrix, is considered a global challenge due to the inherent antibiotic resistance conferred by its lifestyle. Besides, it poses environmental threats causing huge damage in food industries, fisheries, refineries, water systems, pharmaceutical industries, medical industries, etc. Living in a community of microbial populations is most critical in the clinical field, making it responsible for about 80% of severe and chronic microbial diseases. The necessity to find an alternative approach is the need of the hour to solve these crises. So far, many approaches have been attempted to disrupt the initial stage of biofilm formation, including adherence and maturation. Bacteriocins are a group of antimicrobial peptides, produced by bacteria having the potential to disrupt biofilm either by itself or in combination with other drugs than antibiotic counterparts. A clear understanding on mechanisms of bacterial biofilm formation, progression, and resistance will surely lead to the development of innovative, effective biofilm control strategies in pharmaceutical, health care industries and environmental locales.
生物膜是由微生物细胞组成的联合体，被细胞外的聚合基质所保护，由于其生活方式赋予的固有抗生素耐药性，被认为是一个全球性的挑战。此外，它还构成了环境威胁，在食品工业、渔业、炼油厂、水系统、制药工业、医疗工业等领域造成了巨大的破坏。在临床领域，生活在微生物群体中是至关重要的，它导致了大约 80%的严重和慢性微生物疾病。寻找替代方法的必要性是解决这些危机的当务之急。到目前为止，已经尝试了许多方法来破坏生物膜形成的初始阶段，包括附着和成熟。细菌素是一组由细菌产生的抗菌肽，具有破坏生物膜的潜力，无论是单独使用还是与抗生素以外的其他药物联合使用。对细菌生物膜形成、进展和耐药性机制的清晰理解，必将导致在制药、医疗保健行业和环境场所开发创新、有效的生物膜控制策略。
