Insler M S, Helm C J, George W J
Arch Ophthalmol. 1987 Jul;105(7):922-4. doi: 10.1001/archopht.1987.01060070058028.
Twenty-two patients undergoing penetrating keratoplasty received either topical fortified gentamicin (13.6 mg/mL) or a loading dose of intramuscular gentamicin before surgery. Cornea and aqueous humor samples were obtained and assayed by radioimmunoassay for gentamicin. In the topical group, the average gentamicin levels in the cornea and aqueous were 16.2 micrograms/g and 0.3 microgram/mL, respectively. Parenteral drug levels were less variable and averaged 6.1 micrograms/g in the cornea and 0.4 microgram/mL in the aqueous. Although this study demonstrates that parenteral therapy can be used to deliver adequate drug levels to the cornea, it requires far more antibiotic and subjects the patient to potentially toxic systemic side effects. Therefore, topical administration is the preferred route of delivery of antibiotic to the cornea.
22例行穿透性角膜移植术的患者在手术前接受了局部强化庆大霉素（13.6mg/mL）或肌肉注射庆大霉素的负荷剂量。获取角膜和房水样本，并通过放射免疫分析法检测庆大霉素。在局部用药组中，角膜和房水中庆大霉素的平均水平分别为16.2微克/克和0.3微克/毫升。肠道外给药水平变化较小，角膜中平均为6.1微克/克，房水中为0.4微克/毫升。虽然这项研究表明肠道外治疗可用于将足够的药物水平输送至角膜，但它需要更多的抗生素，并使患者面临潜在的全身性毒性副作用。因此，局部给药是向角膜输送抗生素的首选途径。
