放疗后乳腺癌患者的血液淋巴细胞亚群
Blood lymphocyte subpopulations in breast cancer patients following radiotherapy.
作者信息
Petrini B, Wasserman J, Blomgren H, Baral E
出版信息
Clin Exp Immunol. 1977 Jul;29(1):36-42.
Abstract
Both T and non-T lymphocytes decreased immediately following radiotherapy in breast cancer patients. The relative depletion of non-T lymphocytes, however, was more marked than that of T cells. 3 years later the number and the proportion of non-T lymphocytes was higher than immediately after radiotherapy, while T lymphocytes were still depressed. The proportion of cells with membrane-associated Ig was higher in patients 3 years following radiotherapy than in non-treated patients and healthy controls. There was no difference in the proportion of T and non-T lymphocytes between patients with and without metastases, respectively.
摘要
乳腺癌患者放疗后，T淋巴细胞和非T淋巴细胞数量均立即减少。然而，非T淋巴细胞的相对耗竭比T细胞更为明显。3年后，非T淋巴细胞的数量和比例高于放疗刚结束时，而T淋巴细胞仍处于抑制状态。放疗3年后患者中膜相关Ig细胞的比例高于未治疗患者和健康对照。有无转移的患者之间，T淋巴细胞和非T淋巴细胞的比例没有差异。
相似文献
1
Blood lymphocyte subpopulations in breast cancer patients following radiotherapy.放疗后乳腺癌患者的血液淋巴细胞亚群
Clin Exp Immunol. 1977 Jul;29(1):36-42.
2
Blood lymphocyte subpopulations in breast cancer patients following post-operative adjuvant chemotherapy or radiotherapy.乳腺癌患者术后辅助化疗或放疗后的血液淋巴细胞亚群
Clin Exp Immunol. 1979 Nov;38(2):361-5.
3
Effect of radiotherapy on lymphocyte cytotoxicity in vitro.放疗对体外淋巴细胞细胞毒性的影响。
Clin Exp Immunol. 1975 Nov;22(2):230-9.
4
Subpopulations of human T-lymphocytes. XIX. T-cells and T-cells with receptors for IgMFc (T mu), IgGFc (T gamma), or IgAFc (T alpha) in the peripheral blood and regional lymph nodes of patients with untreated breast cancer.人类T淋巴细胞亚群。十九。未经治疗的乳腺癌患者外周血和区域淋巴结中的T细胞以及具有IgM Fc受体（Tμ）、IgG Fc受体（Tγ）或IgA Fc受体（Tα）的T细胞
J Natl Cancer Inst. 1982 Dec;69(6):1261-4.
5
[Intact cellular immune response in patients with locally metastasizing breast carcinoma at the time of diagnosis].[局部转移性乳腺癌患者诊断时完整的细胞免疫反应]
Schweiz Med Wochenschr. 1983 Dec 17;113(50):1908-11.
6
[Differentiation of lymphocyte populations in the blood of breast-cancer patients].
Schweiz Med Wochenschr. 1977 Jul 16;107(28):1010-2.
7
Recovery of lymphocyte function after radiation therapy for cancer in relationship to prognosis.
J Clin Lab Immunol. 1982 Feb;7(2):147-53.
8
9
Alterations in the number of large granular lymphocytes in patients with carcinoma of the breast and uterine cervix prior to and after radiotherapy.
Arch Geschwulstforsch. 1986;56(4):269-72.
10
[Cellular immunity in breast cancer patients].[乳腺癌患者的细胞免疫]
Onkologie. 1982 Aug;5 Suppl:42-5.
引用本文的文献
1
Effect of Radiation Therapy on Composition of Lymphocyte Populations in Patients with Primary Breast Cancer.放射治疗对原发性乳腺癌患者淋巴细胞群体组成的影响。
J Pers Med. 2023 Sep 19;13(9):1399. doi: 10.3390/jpm13091399.
2
Development of a human peripheral blood ex vivo model for rapid protein biomarker detection and applications to radiation biodosimetry.建立人外周血体外模型，快速检测蛋白生物标志物，并应用于辐射生物剂量学。
PLoS One. 2023 Aug 10;18(8):e0289634. doi: 10.1371/journal.pone.0289634. eCollection 2023.
3
Prognostic Significance of the Post-Treatment Neutrophil-to-Lymphocyte Ratio in Pharyngeal Cancers Treated with Concurrent Chemoradiotherapy.同步放化疗治疗的咽癌患者治疗后中性粒细胞与淋巴细胞比值的预后意义
Cancers (Basel). 2023 Feb 16;15(4):1248. doi: 10.3390/cancers15041248.
4
Radiotherapy as a means to increase the efficacy of T-cell therapy in solid tumors.放疗作为提高实体瘤中 T 细胞疗法疗效的手段。
Oncoimmunology. 2022 Dec 22;12(1):2158013. doi: 10.1080/2162402X.2022.2158013. eCollection 2023.
5
Long-Term Effects of Radiation on Lymphocytes and Risk of Opportunistic Infections.辐射对淋巴细胞的长期影响及机会性感染风险
Cureus. 2022 Jul 15;14(7):e26887. doi: 10.7759/cureus.26887. eCollection 2022 Jul.
6
Long-Term Recovery of the Adaptive Immune System in Rhesus Macaques After Total Body Irradiation.恒河猴全身照射后适应性免疫系统的长期恢复
Adv Radiat Oncol. 2021 Apr 19;6(5):100677. doi: 10.1016/j.adro.2021.100677. eCollection 2021 Sep-Oct.
7
Lymphocyte-Sparing Radiotherapy: The Rationale for Protecting Lymphocyte-rich Organs When Combining Radiotherapy With Immunotherapy.淋巴细胞保护放疗：在放疗与免疫治疗联合应用时保护富含淋巴细胞器官的原理。
Semin Radiat Oncol. 2020 Apr;30(2):187-193. doi: 10.1016/j.semradonc.2019.12.003.
8
Irradiation-Related Lymphopenia for Bone Metastasis from Hepatocellular Carcinoma.肝细胞癌骨转移的辐射相关淋巴细胞减少症
Liver Cancer. 2019 Nov;8(6):468-479. doi: 10.1159/000500461. Epub 2019 Jun 21.
9
Delayed recovery of peripheral blood cell numbers after adjuvant cytotoxic chemotherapy for stage II breast cancer.II期乳腺癌辅助细胞毒性化疗后外周血细胞数量的延迟恢复。
Cancer Chemother Pharmacol. 1981;7(1):37-40. doi: 10.1007/BF00258211.
10
T lymphocytes in human cancer--II. Effects of radiotherapy and controlled nutritional intake.
Ir J Med Sci. 1980 Oct;149(10):379-85. doi: 10.1007/BF02939175.
本文引用的文献
1
SEPARATION OF VIABLE LYMPHOCYTES FROM HUMAN BLOOD.从人血中分离活淋巴细胞
Lancet. 1964 Feb 29;1(7331):468-9. doi: 10.1016/s0140-6736(64)90799-8.
2
3
Effect of previous irradiation on the transformation of blood lymphocytes.既往照射对血液淋巴细胞转化的影响。
J Clin Pathol. 1965 Nov;18(6):783-5. doi: 10.1136/jcp.18.6.783.
4
Differential effects of human granulocytes and lymphocytes on human fibroblasts in vitro.人粒细胞和淋巴细胞在体外对人成纤维细胞的不同作用。
Clin Exp Immunol. 1968 Oct;3(8):817-36.
5
Effect of therapeutic irradiation on lymphocyte transformation in lung cancer.治疗性照射对肺癌淋巴细胞转化的影响。
Cancer. 1971 May;27(5):1046-50. doi: 10.1002/1097-0142(197105)27:5<1046::aid-cncr2820270507>3.0.co;2-x.
6
Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytes.纯化淋巴细胞对抗体包被的鸡红细胞的接触性溶解作用。
Cell Immunol. 1970 Sep;1(3):300-15. doi: 10.1016/0008-8749(70)90051-1.
7
Radiation-induced lymphocyte-immune deficiency. A factor in the increased visceral metastases and decreased hormonal responsiveness of breast cancer.辐射诱导的淋巴细胞免疫缺陷。乳腺癌内脏转移增加和激素反应性降低的一个因素。
Arch Surg. 1970 Aug;101(2):114-21. doi: 10.1001/archsurg.1970.01340260018003.
8
Blood lymphocyte replicating ability as a measurement of radiation dosage.
Br J Radiol. 1971 Nov;44(527):834-40. doi: 10.1259/0007-1285-44-527-834.
9
Effect of postoperative radiotherapy on peripheral blood lymphocytes in patients with carcinoma of the breast.术后放疗对乳腺癌患者外周血淋巴细胞的影响。
Cancer. 1972 Feb;29(2):349-56. doi: 10.1002/1097-0142(197202)29:2<349::aid-cncr2820290214>3.0.co;2-k.
10
Immunological characterization of lymphocytes in lymphoproliferative diseases. Restriction of classes, subclasses, and Gm allotypes of membrane-bound Ig.
Scand J Immunol. 1972;1(4):351-60. doi: 10.1111/j.1365-3083.1972.tb03301.x.
Zotero 插件