放疗后乳腺癌患者的血液淋巴细胞亚群
Blood lymphocyte subpopulations in breast cancer patients following radiotherapy.
作者信息
Petrini B, Wasserman J, Blomgren H, Baral E
出版信息
Clin Exp Immunol. 1977 Jul;29(1):36-42.
Abstract
Both T and non-T lymphocytes decreased immediately following radiotherapy in breast cancer patients. The relative depletion of non-T lymphocytes, however, was more marked than that of T cells. 3 years later the number and the proportion of non-T lymphocytes was higher than immediately after radiotherapy, while T lymphocytes were still depressed. The proportion of cells with membrane-associated Ig was higher in patients 3 years following radiotherapy than in non-treated patients and healthy controls. There was no difference in the proportion of T and non-T lymphocytes between patients with and without metastases, respectively.
摘要
乳腺癌患者放疗后，T淋巴细胞和非T淋巴细胞数量均立即减少。然而，非T淋巴细胞的相对耗竭比T细胞更为明显。3年后，非T淋巴细胞的数量和比例高于放疗刚结束时，而T淋巴细胞仍处于抑制状态。放疗3年后患者中膜相关Ig细胞的比例高于未治疗患者和健康对照。有无转移的患者之间，T淋巴细胞和非T淋巴细胞的比例没有差异。
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Blood lymphocyte subpopulations in breast cancer patients following radiotherapy.放疗后乳腺癌患者的血液淋巴细胞亚群
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本文引用的文献
1
SEPARATION OF VIABLE LYMPHOCYTES FROM HUMAN BLOOD.从人血中分离活淋巴细胞
Lancet. 1964 Feb 29;1(7331):468-9. doi: 10.1016/s0140-6736(64)90799-8.
2
3
Effect of previous irradiation on the transformation of blood lymphocytes.既往照射对血液淋巴细胞转化的影响。
J Clin Pathol. 1965 Nov;18(6):783-5. doi: 10.1136/jcp.18.6.783.
4
Differential effects of human granulocytes and lymphocytes on human fibroblasts in vitro.人粒细胞和淋巴细胞在体外对人成纤维细胞的不同作用。
Clin Exp Immunol. 1968 Oct;3(8):817-36.
5
Effect of therapeutic irradiation on lymphocyte transformation in lung cancer.治疗性照射对肺癌淋巴细胞转化的影响。
Cancer. 1971 May;27(5):1046-50. doi: 10.1002/1097-0142(197105)27:5<1046::aid-cncr2820270507>3.0.co;2-x.
6
Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytes.纯化淋巴细胞对抗体包被的鸡红细胞的接触性溶解作用。
Cell Immunol. 1970 Sep;1(3):300-15. doi: 10.1016/0008-8749(70)90051-1.
7
Radiation-induced lymphocyte-immune deficiency. A factor in the increased visceral metastases and decreased hormonal responsiveness of breast cancer.辐射诱导的淋巴细胞免疫缺陷。乳腺癌内脏转移增加和激素反应性降低的一个因素。
Arch Surg. 1970 Aug;101(2):114-21. doi: 10.1001/archsurg.1970.01340260018003.
8
Blood lymphocyte replicating ability as a measurement of radiation dosage.
Br J Radiol. 1971 Nov;44(527):834-40. doi: 10.1259/0007-1285-44-527-834.
9
Effect of postoperative radiotherapy on peripheral blood lymphocytes in patients with carcinoma of the breast.术后放疗对乳腺癌患者外周血淋巴细胞的影响。
Cancer. 1972 Feb;29(2):349-56. doi: 10.1002/1097-0142(197202)29:2<349::aid-cncr2820290214>3.0.co;2-k.
10
Immunological characterization of lymphocytes in lymphoproliferative diseases. Restriction of classes, subclasses, and Gm allotypes of membrane-bound Ig.
Scand J Immunol. 1972;1(4):351-60. doi: 10.1111/j.1365-3083.1972.tb03301.x.
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