Rayburn W, Piehl E, Sanfield J, Compton A
Am J Perinatol. 1987 Jul;4(3):259-61. doi: 10.1055/s-2007-999786.
Glucagon therapy has been used to reverse severe hypoglycemia-induced unconsciousness, but no known study exists which reports its use during pregnancy. Pregnant diabetic women were eligible if they had either a prior hypoglycemic episode requiring intravenous glucose administration or had repeated capillary blood glucose determinations less than 40 mg/dl without any warning adrenergic symptoms. Of 51 insulin-dependent diabetic women, 16 were candidates for glucagon use during a recent 3 1/2-year period. Seven of these 16 persons required an injection on 12 occasions, and an immediate reversal of unconsciousness was encountered in 11 circumstances. No apparent short- or long-term maternal adverse effects were present. We conclude that glucagon therapy is needed infrequently for diabetic women during pregnancy but is helpful in reversing acute episodes of severe hypoglycemia.
胰高血糖素疗法已被用于逆转严重低血糖导致的昏迷，但尚无已知研究报道其在孕期的使用情况。如果妊娠糖尿病女性既往有需要静脉输注葡萄糖治疗的低血糖发作史，或多次毛细血管血糖测定低于40mg/dl且无任何肾上腺素能症状预警，则符合使用胰高血糖素的条件。在51例胰岛素依赖型糖尿病女性中，有16例在最近3年半的时间里有使用胰高血糖素的指征。这16例中的7例在12次情况下需要注射胰高血糖素，其中11次昏迷立即得到逆转。未出现明显的短期或长期母体不良反应。我们得出结论，孕期糖尿病女性很少需要胰高血糖素治疗，但它有助于逆转严重低血糖的急性发作。
