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与试行保守排石相比,对有症状的肾结石和输尿管结石进行早期外科干预与减少阿片类药物需求相关。

Early Surgical Intervention for Symptomatic Renal and Ureteral Stones is Associated With Reduced Narcotic Requirement Relative to Trial of Passage.

机构信息

Indiana University School of Medicine, Department of Urology, Indianapolis, IN.

Indiana University School of Medicine, Department of Urology, Indianapolis, IN.

出版信息

Urology. 2020 Dec;146:59-66. doi: 10.1016/j.urology.2020.08.063. Epub 2020 Sep 29.

Abstract

OBJECTIVES

To evaluate if trial of passage (TOP) or initial surgical intervention resulted in less narcotic analgesia utilization in patients with acute renal colic due to stone disease.

METHODS

We retrospectively evaluated 135 patients with acute renal colic due to nephroureterolithiasis managed by a single surgeon. Patients were standardly offered TOP or surgical intervention with ureteroscopy (URS). A subset of patients were stented with delayed URS due to presence of infection, pain, or a nonaccommodating ureter. Our standard practice is narcotic-free URS, prescribing a stent cocktail including non-steroidal anti-inflammatories. We compared rates of narcotic prescription over the entire treatment course for patients electing TOP vs surgery (primary or delayed URS). We secondarily analyzed rates of surgical intervention among initial TOP.

RESULTS

We included 135 patients, with 69 (51.1%) TOP as initial treatment, 39 (28.9%) stent with delayed URS, and 27 (20.0%) primary URS. Thirty-nine (56.5%) TOP patients underwent URS at a median time of 18 days (IQR 6-31 days) from diagnosis. More TOP patients required a narcotic prescription (60.9% vs 35.9% vs 33.3%, respectively; P = .010) compared to patients undergoing initial stent or URS. However, when an opioid prescription was provided, the total morphine milligram equivalents prescribed among each group was not statistically significant.

CONCLUSION

Patients electing initial treatment with TOP for renal colic due to stone disease were more likely to require narcotic prescriptions than patients electing initial surgical intervention.

摘要

目的

评估经尿道扩张(TOP)或初始手术干预是否可减少因结石病导致的急性肾绞痛患者对阿片类镇痛药的使用。

方法

我们回顾性评估了由一位外科医生治疗的 135 例因肾盂输尿管结石病导致的急性肾绞痛患者。标准方案为向患者提供 TOP 或经输尿管镜(URS)手术治疗。由于存在感染、疼痛或不适应的输尿管,一部分患者会接受带延迟 URS 的支架治疗。我们的标准治疗方法是无阿片类药物的 URS,并开具包括非甾体抗炎药在内的支架鸡尾酒处方。我们比较了选择 TOP 与手术(原发性或延迟 URS)治疗的患者在整个治疗过程中开阿片类药物处方的比率。我们还对初始 TOP 患者中手术干预的比率进行了二次分析。

结果

我们纳入了 135 例患者,其中 69 例(51.1%)作为初始治疗选择 TOP,39 例(28.9%)支架带延迟 URS,27 例(20.0%)原发性 URS。39 例(56.5%)TOP 患者在诊断后中位数 18 天(IQR 6-31 天)时进行了 URS。与接受初始支架或 URS 的患者相比,选择 TOP 进行初始治疗的患者更需要开具阿片类药物处方(分别为 60.9%、35.9%和 33.3%;P=0.010)。然而,当开具阿片类药物处方时,每组患者开具的总吗啡毫克当量并无统计学差异。

结论

选择经尿道扩张治疗因结石病导致的肾绞痛的患者比选择初始手术干预的患者更有可能需要开具阿片类药物处方。

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