Department of Microbiology, Pondicherry University, Puducherry 605014, India.
Department of Food Science and Technology, Pondicherry University, Puducherry 605014, India.
Virus Res. 2020 Dec;290:198175. doi: 10.1016/j.virusres.2020.198175. Epub 2020 Sep 29.
The outbreak and spread of new strains of coronavirus (SARS-CoV-2) remain a global threat with increasing cases in affected countries. The evolutionary tree of SARS-CoV-2 revealed that Porcine Reproductive and Respiratory Syndrome virus 2, which belongs to the Beta arterivirus genus from the Arteriviridae family is possibly the most ancient ancestral origin of SARS-CoV-2 and other Coronaviridae. This review focuses on phylogenomic distribution and evolutionary lineage of zoonotic viral cross-species transmission of the Coronaviridae family and the implications of bat microbiome in zoonotic viral transmission and infection. The review also casts light on the role of the human microbiome in predicting and controlling viral infections. The significance of microbiome-mediated interventions in the treatment of viral infections is also discussed. Finally, the importance of synthetic viruses in the study of viral evolution and transmission is highlighted.
新型冠状病毒（SARS-CoV-2）的爆发和传播仍然是一个全球性威胁，受影响国家的病例不断增加。SARS-CoV-2 的进化树表明，属于动脉炎病毒科动脉病毒属的猪繁殖与呼吸综合征病毒 2 可能是 SARS-CoV-2 和其他冠状病毒科的最古老的祖先起源。本综述重点介绍了冠状病毒科人畜共患病毒跨物种传播的系统基因组分布和进化谱系，以及蝙蝠微生物组在人畜共患病毒传播和感染中的作用。该综述还探讨了人类微生物组在预测和控制病毒感染中的作用。此外，还讨论了微生物组介导的干预在治疗病毒感染中的重要性。最后，强调了合成病毒在研究病毒进化和传播中的重要性。
