Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore.
Virology Unit, Institut Pasteur du Cambodge, Pasteur Network, Phnom Penh 120210, Cambodia.
Viruses. 2022 Jan 18;14(2):176. doi: 10.3390/v14020176.
Bats have been recognized as an exceptional viral reservoir, especially for coronaviruses. At least three bat zoonotic coronaviruses (SARS-CoV, MERS-CoV and SARS-CoV-2) have been shown to cause severe diseases in humans and it is expected more will emerge. One of the major features of CoVs is that they are all highly prone to recombination. An extreme example is the insertion of the P10 gene from reoviruses in the bat CoV GCCDC1, first discovered in bats in China. Here, we report the detection of GCCDC1 in four different bat species (, , and sp.) in Cambodia. This finding demonstrates a much broader geographic and bat species range for this virus and indicates common cross-species transmission. Interestingly, one of the bat samples showed a co-infection with an Alpha CoV most closely related to RsYN14, a virus recently discovered in the same genus () of bat in Yunnan, China, 2020. Taken together, our latest findings highlight the need to conduct active surveillance in bats to assess the risk of emerging CoVs, especially in Southeast Asia.
蝙蝠已被公认为是一种特殊的病毒储存库，尤其是冠状病毒。至少有三种蝙蝠源性人畜共患冠状病毒（SARS-CoV、MERS-CoV 和 SARS-CoV-2）已被证明会导致人类严重疾病，预计还会有更多的病毒出现。冠状病毒的一个主要特征是它们都非常容易发生重组。一个极端的例子是在中国蝙蝠中首次发现的 bat CoV GCCDC1 中，来自呼肠孤病毒的 P10 基因的插入。在这里，我们报告了在柬埔寨的四种不同蝙蝠物种（,, 和 sp.）中检测到 GCCDC1。这一发现表明该病毒的地理范围和蝙蝠物种范围更加广泛，表明存在常见的跨物种传播。有趣的是，其中一个蝙蝠样本显示与 RsYN14 密切相关的 Alpha CoV 混合感染，该病毒最近在中国云南同一属（）的蝙蝠中发现，时间是 2020 年。综上所述，我们的最新发现强调了需要在蝙蝠中进行积极监测，以评估新兴冠状病毒的风险，特别是在东南亚。
