两种自然重组产生了柯萨奇病毒 B3GV，该病毒导致了 2006-2012 年在中国的爆发。
Two Natural Recombination gave rise to the Coxsackievirus B3 GV that triggered outbreaks in China in 2006 - 2012.
机构信息
Medical College, Jiangsu University, 301, Xuefu road, 212013 Zhenjiang, P. R. China.
Taizhou fourth people's hospital, 99, Gulou road, 225300 Taizhou, P. R. China.
出版信息
Infect Dis Now. 2021 Feb;51(1):81-85. doi: 10.1016/j.medmal.2020.09.008. Epub 2020 Sep 29.
Coxsackievirus B3 serotype GV caused the epidemic of Coxsackievirus B3 infection in China from 2006 to 2012. To study the evolution and recombination of Coxsackievirus B3 serotype GV, we performed recombination and phylogenetic analysis of 499 complete genomes of Enterovirus B available in GenBank, dated April 2019. Results indicated that most of the strains of Coxsackievirus B3 GV in P1 region were derived from a Coxsackievirus B3 GVI parent, and in P2-3 region from EchoV E25 strain, with nucleotide identities of 97.2% and 94.7%, respectively. Other strains of Coxsackievirus B3 GV-C1 in P1-P2 regions were derived from Coxsackievirus B3 GV-C3, whereas those in P3 regions were from CVB5. These naturally occurring recombination events were confirmed by phylogenetic analysis. This study indicates that two naturally occurring recombination gave rise to the coxsackievirus B3 GV that triggered outbreaks in China in 2006 - 2012.
柯萨奇病毒 B3 血清型 GV 引起了 2006 年至 2012 年中国柯萨奇病毒 B3 感染的流行。为了研究柯萨奇病毒 B3 血清型 GV 的进化和重组，我们对 2019 年 4 月 GenBank 中可用的 499 个肠病毒 B 完整基因组进行了重组和系统发育分析。结果表明，P1 区的大多数柯萨奇病毒 B3 GV 株来自柯萨奇病毒 B3 GVI 亲本，而 P2-3 区则来自 EchoV E25 株，核苷酸同一性分别为 97.2%和 94.7%。P1-P2 区的其他柯萨奇病毒 B3 GV-C1 株来源于柯萨奇病毒 B3 GV-C3，而 P3 区则来源于 CVB5。这些自然发生的重组事件通过系统发育分析得到了证实。本研究表明，两次自然发生的重组事件导致了 2006-2012 年在中国引发疫情的柯萨奇病毒 B3 GV 的产生。
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