Shen Hongxing
Medical College, Jiangsu University, 301 Xuefu Road, 212013, Zhenjiang, People's Republic of China.
Arch Virol. 2018 Feb;163(2):539-544. doi: 10.1007/s00705-017-3608-6. Epub 2017 Nov 13.
Coxsackievirus B5 (CVB5) is a member of the species Enterovirus B of the genus Enterovirus, family Picornaviridae. Based on its VP1 sequence, CVB5 is divided into four genogroups: A, B, C, and D. From 2002 to 2012, CVB5 serotype genogroup C caused an outbreak of aseptic meningitis in China. In order to study the evolution of CVB5 genogroup C, phylogenetic and recombination analysis was performed using the 399 available enterovirus B genome sequences in the GenBank database. The results indicated that 10 strains of CVB5 serotype genogroup C resulted from recombination between members of genogroup B and echovirus serotype E6, and another 5 strains resulted from recombination between members of genogroup C and serotype CVB4. These recombination events were confirmed by phylogenetic analysis.
柯萨奇病毒B5（CVB5）是小RNA病毒科肠道病毒属肠道病毒B种的成员。基于其VP1序列，CVB5分为四个基因群：A、B、C和D。2002年至2012年，CVB5血清型基因群C在中国引发了无菌性脑膜炎疫情。为了研究CVB5基因群C的进化，利用GenBank数据库中399条可用的肠道病毒B基因组序列进行了系统发育和重组分析。结果表明，10株CVB5血清型基因群C菌株是由基因群B成员与埃可病毒血清型E6之间的重组产生的，另外5株是由基因群C成员与血清型CVB4之间的重组产生的。这些重组事件通过系统发育分析得到了证实。
