O'Boyle C A, Harris D, Barry H, McCreary C, Bewley A, Fox E
Br J Anaesth. 1987 Jun;59(6):746-54. doi: 10.1093/bja/59.6.746.
In a randomized double-blind, parallel groups study, 40 patients undergoing surgical removal of impacted 3rd molar teeth received either midazolam 15 mg orally followed at 35 min by i.v. saline, or oral placebo followed at 35 min by i.v. diazepam 10 mg (Diazemuls). Rapid onset of sedation was seen after midazolam, while the pattern and duration of postoperative sedation, as measured by standard psychometric tests, indicated slower recovery after midazolam than after diazepam. Ratings by the surgeon indicated superior anxiolysis following midazolam and significantly more patients expressed a preference for oral midazolam sedation. Significant, comparable anterograde amnesia was seen with both treatments. No significant cardiovascular complications occurred with either treatment. The findings indicate that rapidly acting oral benzodiazepines such as midazolam provide safe, effect alternatives to i.v. diazepam for conscious sedation in outpatients undergoing minor surgical procedures.
在一项随机双盲平行组研究中，40例接受阻生第三磨牙拔除手术的患者，要么口服15毫克咪达唑仑，35分钟后静脉注射生理盐水，要么口服安慰剂，35分钟后静脉注射10毫克地西泮（安定乳剂）。咪达唑仑给药后出现快速镇静，而通过标准心理测试测量的术后镇静模式和持续时间表明，咪达唑仑组比地西泮组恢复得更慢。外科医生的评分表明，咪达唑仑的抗焦虑效果更佳，并且更多患者表示更倾向于口服咪达唑仑镇静。两种治疗方法均出现显著且相当的顺行性遗忘。两种治疗均未出现显著的心血管并发症。研究结果表明，对于接受小型外科手术的门诊患者进行清醒镇静时，快速起效的口服苯二氮䓬类药物如咪达唑仑，是静脉注射地西泮的安全有效替代方案。
