O'Boyle C A, Barry H, Fox E, McCreary C, Bewley A
Research Department, Eastern Health Board, Dublin, Ireland.
Br J Anaesth. 1988 Mar;60(4):419-25. doi: 10.1093/bja/60.4.419.
In a randomized, double-blind, parallel groups study, 40 patients undergoing surgical removal of impacted 3rd molar teeth received either sublingual lormetazepam 2.5 mg (n = 20) in a new cellulose wafer formulation followed at 35 min by i.v. saline; or sublingual placebo followed at 35 min by i.v. diazepam 10 mg (Diazemuls). Rapid onset of sedation was seen after sublingual lormetazepam, while the course and duration of postoperative sedation, measured using standard psychometric tests, was similar following both treatments. Surgeons' ratings indicated that sublingual lormetazepam was comparable to i.v. diazepam but patients' ratings indicated greater satisfaction with and preference for i.v. diazepam. Significant anterograde amnesia was found following both treatments. Both treatments were tolerated well, with no significant cardiovascular complications. These results indicate that sublingual lormetazepam may have a role in anaesthesia as a premedicant and for conscious sedation.
在一项随机、双盲、平行组研究中，40例接受阻生第三磨牙拔除手术的患者，一组接受新的纤维素片剂型的舌下氯美扎酮2.5毫克（n = 20），35分钟后静脉注射生理盐水；另一组接受舌下安慰剂，35分钟后静脉注射地西泮10毫克（安定乳剂）。舌下氯美扎酮用药后镇静作用迅速起效，而采用标准心理测量测试评估，两种治疗术后镇静的过程和持续时间相似。外科医生的评分表明，舌下氯美扎酮与静脉注射地西泮相当，但患者的评分表明，患者对静脉注射地西泮的满意度更高且更倾向于选择它。两种治疗后均发现有明显的顺行性遗忘。两种治疗的耐受性均良好，无明显心血管并发症。这些结果表明，舌下氯美扎酮在麻醉中作为术前用药和用于清醒镇静可能有一定作用。
