Chang Chin-Chuan, Yang Ming-Hui, Liu Chih-Ting, Chu Hsiu-Lan, Lin Chia-Yang, Yen Wei-Jheng, Chung Chao-Yu, Ho Sheng-Yow, Tyan Yu-Chang
Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.
Department of Electrical Engineering, I-Shou University, Kaohsiung 84001, Taiwan.
Diagnostics (Basel). 2020 Sep 30;10(10):772. doi: 10.3390/diagnostics10100772.
This study aimed to investigate the diagnostic performance of semi-quantitative parameters of thallium-201 myocardial perfusion imaging (MPI) for coronary artery disease (CAD). From January to December 2017, patients were enrolled who had undergone Tl-201 MPI and received cardiac catheterization for coronary artery disease within three months of MPI. Receiver operating characteristics (ROC) analysis was used to determine the optimal cutoff values of semi-quantitative parameters. A comparison of the sensitivity and specificity of these parameters based on different subgroupings was further performed. A total of 130 patients were enrolled for further analysis. Among the collected parameters, the stress total perfusion deficit (sTPD) had the highest value of the area under curve (0.813) under the optimal cutoff value of 3.5%, with a sensitivity and specificity of 73.5% and 74.5%, respectively ( = 0.0000), for the diagnosis of CAD. With further subgrouping analysis based on history of diabetes or dyslipidemia, the sensitivity and specificity showed similar results. Based on the currently collected data and image acquisition conditions, the sTPD parameter has a clinical role for the diagnosis of CAD with a cutoff value of 3.5%.
本研究旨在探讨201铊心肌灌注显像（MPI）半定量参数对冠状动脉疾病（CAD）的诊断效能。2017年1月至12月，纳入在MPI检查后三个月内接受过201铊MPI检查并因冠状动脉疾病接受心脏导管检查的患者。采用受试者操作特征（ROC）分析确定半定量参数的最佳截断值。进一步对基于不同亚组的这些参数的敏感性和特异性进行比较。共纳入130例患者进行进一步分析。在所收集的参数中，静息总灌注缺损（sTPD）在最佳截断值3.5%时曲线下面积最高（0.813），诊断CAD的敏感性和特异性分别为73.5%和74.5%（P = 0.0000）。基于糖尿病或血脂异常病史进行进一步亚组分析时，敏感性和特异性显示出相似结果。根据目前收集的数据和图像采集条件，sTPD参数在截断值为3.5%时对CAD诊断具有临床意义。
