School of Life Sciences, University of Westminster, London W1W 6UW, UK.
School of Health Sciences, Faculty of Education, Health and Human Sciences, University of Greenwich, London SE9 2UG, UK.
Int J Environ Res Public Health. 2020 Sep 30;17(19):7182. doi: 10.3390/ijerph17197182.
The relationship between osteoporosis and lactose intolerance is unclear. This study aims to evaluate the association between self-reported lactose intolerance and symptom severity caused by lactose malabsorption and bone mineral density (BMD). A total of 496 American hip arthroplasty patients took part in this study. Information on BMD and socio-demographic factors were retrospectively extracted from medical records. BMD of the lumbar spine (LS), femoral neck of the operative hip (FNOH), and femoral neck of the non-operative hip (FNH) were measured via dual-energy x-ray absorptiometry scans (DXA). Patients also completed a survey regarding dietary and lifestyle habits from the time of surgery. We found that 9.3% of participants reported lactose intolerance and 33.3%% suffered from either osteopenia or osteoporosis in at least one (location. The population that did not self-identify as lactose intolerant consumed significantly more dairy ( < 0.0001) and animal protein ( = 0.004) than those with intolerance. There was no significant difference in BMD between self-identified lactose intolerant individuals and non-lactose intolerant individuals. In a stepwise multiple regression analysis, body mass index (BMI) and age were the only common predictors of BMD for all locations ( < 0.05). However, yogurt intake was a significant predictor of BMD of FNOH in the multivariate analysis. This study suggests that lactose intolerance is not associated with bone mineral density. We also found that being vegan or vegetarian may increase the risk of low BMD.
骨质疏松症和乳糖不耐受之间的关系尚不清楚。本研究旨在评估乳糖不耐受与乳糖吸收不良引起的症状严重程度和骨密度（BMD）之间的关系。共有 496 名美国髋关节置换术患者参与了这项研究。从病历中回顾性提取了 BMD 和社会人口统计学因素的信息。通过双能 X 射线吸收法（DXA）测量了腰椎（LS）、手术髋关节股骨颈（FNOH）和非手术髋关节股骨颈（FNH）的 BMD。患者还完成了一项关于手术时饮食和生活方式的调查。我们发现，9.3%的参与者报告有乳糖不耐受，33.3%的参与者至少在一个部位患有骨质疏松症或骨量减少。自我认同为乳糖不耐受的人群的乳制品（<0.0001）和动物蛋白（=0.004）的摄入量明显高于不耐受人群。自我认同为乳糖不耐受的个体与非乳糖不耐受的个体之间的 BMD 没有显著差异。在逐步多元回归分析中，体质指数（BMI）和年龄是所有部位 BMD 的唯一共同预测因子（<0.05）。然而，在多元分析中，酸奶的摄入量是 FNOH 骨密度的一个显著预测因子。本研究表明，乳糖不耐受与骨密度无关。我们还发现，素食或纯素食可能会增加低 BMD 的风险。
