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植物晶体——用于提高药用植物生物功效的纳米级植物材料。

PlantCrystals-Nanosized Plant Material for Improved Bioefficacy of Medical Plants.

作者信息

Abraham Abraham M, Alnemari Reem M, Jacob Claus, Keck Cornelia M

机构信息

Department of Pharmaceutics and Biopharmaceutics, Philipps-Universität Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany.

Department of Bioorganic Chemistry, Universität des Saarlandes, Campus, Geb. B2.1, 66123 Saarbrücken, Germany.

出版信息

Materials (Basel). 2020 Sep 30;13(19):4368. doi: 10.3390/ma13194368.

DOI:10.3390/ma13194368
PMID:33008071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7578979/
Abstract

UNLABELLED

PlantCrystals are obtained by milling plant material to sizes <10 µm. Due to the disruption of the plant cells, active compounds are easily released, rendering the PlantCrystal technology an effective and low-cost process for the production of environmentally friendly plant extracts. The extracts can be used to produce phytomedicines, nutritional supplements or cosmetic products. Previous studies could already demonstrate the use of PlantCrystals to improve the antimicrobial or antifungal activity of different plants. This study investigated whether PlantCrystal technology is suitable to produce plant derived formulations with high antioxidant capacity. The study also aimed to identify the most suitable production methods for this.

METHODS

Various plant materials and parts of plants, i.e., seeds, leaves and flowers, and different methods were employed for the production. PlantCrystals were characterized regarding size, physical stability and antioxidant capacity (AOC).

RESULTS

PlantCrystals with particles <1 µm were produced from the different plant materials. Both production methods, i.e., high-pressure homogenization, bead milling or the combination of both were suitable to obtain PlantCrystals. Nano milling of the plant material greatly affected their AOC and resulted in formulations with distinctly higher AOC when compared to classical extracts.

CONCLUSIONS

Rendering plant material into small sized particles is highly effective to obtain plant extracts with high biological efficacy.

摘要

未标注

植物晶体是通过将植物材料研磨至尺寸小于10微米而获得的。由于植物细胞的破裂，活性化合物易于释放，这使得植物晶体技术成为生产环保型植物提取物的一种有效且低成本的方法。这些提取物可用于生产植物药、营养补充剂或化妆品。先前的研究已经能够证明使用植物晶体可提高不同植物的抗菌或抗真菌活性。本研究调查了植物晶体技术是否适合生产具有高抗氧化能力的植物源制剂。该研究还旨在确定最适合的生产方法。

方法

采用了各种植物材料和植物部位，即种子、叶子和花朵，并使用了不同的方法进行生产。对植物晶体的尺寸、物理稳定性和抗氧化能力（AOC）进行了表征。

结果

由不同植物材料制得的植物晶体颗粒小于1微米。两种生产方法，即高压均质化、珠磨或两者结合，都适合获得植物晶体。与传统提取物相比，对植物材料进行纳米研磨极大地影响了它们的AOC，并得到了具有明显更高AOC的制剂。

结论

将植物材料制成小尺寸颗粒对于获得具有高生物功效的植物提取物非常有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2537/7578979/eb100e276dae/materials-13-04368-g015.jpg
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