Pattanakitsakul Ploy, Chongviriyaphan Nalinee, Pakakasama Samart, Apiwattanakul Nopporn
Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand.
BMC Res Notes. 2020 Oct 2;13(1):464. doi: 10.1186/s13104-020-05307-8.
Vitamin A is involved in maintenance of gut mucosal integrity and normal immune function. However, it is unclear whether these functions of vitamin A have any beneficial effects in patients undergoing hematopoietic stem cell transplantation (HSCT). In this study, we aimed to examine the potential protective effect of vitamin A supplementation on gastrointestinal (GI) mucosal integrity in HSCT recipients using plasma citrulline as a surrogate marker of intestinal integrity.
We performed a quasi-randomized trial in 30 pediatric patients undergoing HSCT. Half (n = 15) of the patients received a single high dose of vitamin A (200,000 IU) before the conditioning regimen was given, and half (n = 15) did not. Clinical data of patients who developed post-transplant complications were recorded for 60 days after HSCT. There were no significant differences in mean plasma citrulline levels on day 7 after HSCT between the treatment and control groups (5.8 vs. 5.9 µmol/L, respectively). The incidence of mucositis and other complications were not different between the two groups within 60 days of HSCT. Vitamin A supplementation prior to HSCT in pediatric patients had no clinical benefit in protecting GI mucosal integrity.
维生素A参与维持肠道黏膜完整性和正常免疫功能。然而，维生素A的这些功能对接受造血干细胞移植（HSCT）的患者是否有任何有益作用尚不清楚。在本研究中，我们旨在以血浆瓜氨酸作为肠道完整性的替代标志物，研究补充维生素A对HSCT受者胃肠道（GI）黏膜完整性的潜在保护作用。
我们对30例接受HSCT的儿科患者进行了一项半随机试验。一半（n = 15）患者在给予预处理方案前接受单次高剂量维生素A（200,000 IU），另一半（n = 15）未接受。记录HSCT后60天内发生移植后并发症患者的临床数据。HSCT后第7天，治疗组和对照组的平均血浆瓜氨酸水平无显著差异（分别为5.8和5.9 μmol/L）。在HSCT后60天内，两组之间的黏膜炎和其他并发症发生率无差异。儿科患者在HSCT前补充维生素A对保护GI黏膜完整性无临床益处。
