Department of Hematology & Oncology, Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute, Hess CSM Building 1470 Madison Avenue, New York, NY 10029, USA.
Department of Hematology & Oncology, Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute, 1470 Madison Avenue, New York, NY 10029, USA.
Urol Clin North Am. 2020 Nov;47(4):433-442. doi: 10.1016/j.ucl.2020.07.002. Epub 2020 Sep 2.
Natural killer (NK) cells are potently cytolytic innate lymphocytes involved in the immune surveillance of tumors and virally infected cells. Although much progress has been made in manipulating the ability of T cells to recognize and eliminate tumors, a comprehensive understanding of NK-cell infiltration into solid tumors, and their amenability to immunomodulation, remains incomplete. This article discusses recent studies showing that urologic tumors are infiltrated by NK cells and that these NK cells are often dysfunctional, but that strategies interfering with inhibitory axes have significant potential to alleviate this dysfunction.
自然杀伤 (NK) 细胞是一种强有力的细胞溶解性先天淋巴细胞，参与肿瘤和病毒感染细胞的免疫监视。尽管在操纵 T 细胞识别和消除肿瘤的能力方面已经取得了很大进展，但对 NK 细胞浸润实体瘤及其对免疫调节的易感性的全面理解仍不完整。本文讨论了最近的研究表明，泌尿系统肿瘤浸润 NK 细胞，这些 NK 细胞通常功能失调，但干扰抑制轴的策略具有显著缓解这种功能失调的潜力。
