Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, Saitama Medical Center, Saitama, Japan.
Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, Saitama Medical Center, Saitama, Japan.
J Infect Chemother. 2021 Feb;27(2):350-353. doi: 10.1016/j.jiac.2020.09.017. Epub 2020 Sep 30.
Hypervirulent Klebsiella pneumoniae capsular genotypes K1 and K2 are common pathogens responsible for community-acquired liver abscesses and invasive infections especially in East Asia. We report a Japanese man with diabetes mellitus who rapidly developed emphysematous cholecystitis and fulminant disseminated infection with life-threatening multiple organ-system failure due to K. pneumoniae K2 strains belonging to sequence type 65. In East Asia, clinicians should be aware of fulminant infections caused by hypervirulent K2 strains in patients with community-acquired K. pneumoniae infections. Further epidemiological studies are warranted to elucidate the clinical features associated with the virulence K. pneumoniae K2 strains.
高毒力肺炎克雷伯菌荚膜血清型 K1 和 K2 是常见的病原体，可导致社区获得性肝脓肿和侵袭性感染，尤其在东亚地区更为常见。我们报告了一例患有糖尿病的日本男性患者，由于属于 65 型序列类型的肺炎克雷伯菌 K2 株，迅速发展为气肿性胆囊炎和暴发性播散性感染，并伴有危及生命的多器官系统衰竭。在东亚地区，临床医生应注意社区获得性肺炎克雷伯菌感染患者中由高毒力 K2 株引起的暴发性感染。有必要进行进一步的流行病学研究，以阐明与毒力较强的肺炎克雷伯菌 K2 株相关的临床特征。
