Institute of Social and Preventive Medicine, University of Bern, Switzerland.
Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Am J Gastroenterol. 2020 Dec;115(12):2098-2102. doi: 10.14309/ajg.0000000000000957.
We investigated whether dilation modifies the association between symptoms and esophageal eosinophilia (peak esophageal eosinophils/high-power field [eos/hpf]) in patients with eosinophilic esophagitis enrolled into a randomized trial comparing the efficacy of budesonide and fluticasone.
Baseline Dysphagia Symptom Questionnaire and Eosinophilic Esophagitis Activity Index were available in 102 and 73 patients, respectively, of whom 56 and 39 underwent dilation at screening endoscopy before symptom assessment. The pair-wise relationship between Dysphagia Symptom Questionnaire, Eosinophilic Esophagitis Activity Index, and eos/hpf was analyzed with nonparametric correlations.
In nondilated patients, the association between baseline eos/hpf and symptoms was moderate and significant, although it was abolished in dilated patients.
Dilation modifies association between symptoms and eos/hpf (clinicaltrials.gov NCT02019758).
我们研究了在一项比较布地奈德和氟替卡松疗效的随机试验中招募的嗜酸性食管炎患者中，扩张是否改变了症状与食管嗜酸性粒细胞增多（食管嗜酸性粒细胞高峰/高倍视野 [eos/hpf]）之间的关联。
102 名患者有基线吞咽困难症状问卷，73 名患者有嗜酸性食管炎活动指数，其中 56 名和 39 名在症状评估前的筛查内镜检查时进行了扩张。使用非参数相关性分析了吞咽困难症状问卷、嗜酸性食管炎活动指数和 eos/hpf 之间的两两关系。
在未扩张的患者中，基线 eos/hpf 与症状之间的关联是中度且显著的，但在扩张的患者中这种关联消失了。
扩张改变了症状与 eos/hpf 之间的关联（clinicaltrials.gov NCT02019758）。
