Dr Shterev Hospital, Sofia, Bulgaria.
Medical University of Plovdiv, Plovdiv, Bulgaria.
Folia Med (Plovdiv). 2020 Sep 30;62(3):597-600. doi: 10.3897/folmed.62.e50166.
Insulin-induced lipoatrophy is a rare skin complication in patients with diabetes mellitus. It is characterized primarily by localized subcutaneous atrophy of the fatty tissue at the site of frequent insulin injection. We report a clinical case of a 38-year-old woman with lipoatrophy, developed during treatment with insulin analogues. Lipoatrophic zone formation began 3 months after the treatment was initiated. A lipoatrophic defect developed on the thighs and the upper outer arms, resulting from repeated insulin injections at the same site. Regarding lipoatrophic areas, treatment with topical administration of corticosteroids was attempted but without a significant clinical effect. The best prevention from lipoatrophy development is education of patients regarding rotation of insulin injection sites and more frequent needle change.
胰岛素诱导的脂肪萎缩是糖尿病患者罕见的皮肤并发症。其主要特征是频繁注射胰岛素部位的局部皮下脂肪组织萎缩。我们报告了一例 38 岁女性的脂肪萎缩临床病例，该病例发生在使用胰岛素类似物治疗期间。脂肪萎缩区形成始于治疗开始后 3 个月。由于在同一部位反复注射胰岛素，大腿和上臂外上侧出现脂肪萎缩缺陷。对于脂肪萎缩区域，尝试了局部皮质类固醇治疗，但临床效果不明显。预防脂肪萎缩发展的最佳方法是教育患者关于胰岛素注射部位的轮换和更频繁的针头更换。
