评价透明质酸纳米粒子嵌入壳聚糖-明胶水凝胶中的抗生素释放情况。
Evaluation of hyaluronic acid nanoparticle embedded chitosan-gelatin hydrogels for antibiotic release.
机构信息
Department of Polymer Engineering, Hitit University, Çorum, Turkey.
Department of Chemical Engineering, Hitit University, Çorum, Turkey.
出版信息
Drug Dev Res. 2021 Apr;82(2):241-250. doi: 10.1002/ddr.21747. Epub 2020 Oct 3.
The development of chitosan-gelatin (CS-G) hydrogels embedded with ampicillin-loaded hyaluronic acid nanoparticles (HA-NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA-NPs into biocompatible CS-G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS-G/HA-NPs hydrogels after 5 days. Antibacterial performance of CS-G/HA-NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS-G/HA-NPs hydrogels compared with CS-G group after 24 hr incubation. Consequently, the potential ability of CS-G/HA-NPs hydrogels as a controlled drug delivery system has been verified.
提出了一种壳聚糖-明胶（CS-G）水凝胶中嵌入载氨苄西林透明质酸纳米颗粒（HA-NPs）用于伤口敷料的方法。其目的是通过将 HA-NPs 掺入到生物相容性 CS-G 水凝胶结构中来提供对氨苄西林的控制释放。根据体外氨苄西林释放研究，在 5 天后，CS-G/HA-NPs 水凝胶中释放了 55%的氨苄西林。琼脂圆盘扩散试验证明了 CS-G/HA-NPs 水凝胶的抗菌性能。对于细胞毒性试验，与 CS-G 组相比，在 24 小时孵育后，CS-G/HA-NPs 水凝胶中的成纤维细胞活力增加。因此，CS-G/HA-NPs 水凝胶作为一种控制药物释放系统的潜在能力已经得到了验证。
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