抗菌天然水凝胶在生物医学中的应用：性质、应用和挑战——简要综述。

Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University, 20031 Lublin, Poland.

Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Int J Mol Sci. 2023 Jan 22;24(3):2191. doi: 10.3390/ijms24032191.

Natural hydrogels are widely used as biomedical materials in many areas, including drug delivery, tissue scaffolds, and particularly wound dressings, where they can act as an antimicrobial factor lowering the risk of microbial infections, which are serious health problems, especially with respect to wound healing. In this review article, a number of promising strategies in the development of hydrogels with biocidal properties, particularly those originating from natural polymers, are briefly summarized and concisely discussed. Common strategies to design and fabricate hydrogels with intrinsic or stimuli-triggered antibacterial activity are exemplified, and the mechanisms lying behind these properties are also discussed. Finally, practical antibacterial applications are also considered while discussing the current challenges and perspectives.

天然水凝胶在许多领域被广泛用作生物医学材料，包括药物输送、组织支架，特别是伤口敷料，它们可以作为抗菌因子，降低微生物感染的风险，微生物感染是严重的健康问题，尤其是在伤口愈合方面。在这篇综述文章中，简要总结并简要讨论了具有杀菌性能的水凝胶的一些有前途的开发策略，特别是那些源自天然聚合物的策略。举例说明了设计和制造具有内在或刺激触发抗菌活性的水凝胶的常见策略，并讨论了这些特性背后的机制。最后，在讨论当前的挑战和展望时，还考虑了实际的抗菌应用。