Alipoor Reza, Ayan Mohammad, Hamblin Michael R, Ranjbar Reza, Rashki Somaye
Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Sina Higher Education Institute, Kashan, Iran.
Front Bioeng Biotechnol. 2022 Jun 8;10:913912. doi: 10.3389/fbioe.2022.913912. eCollection 2022.
Bacterial contamination of medical devices is a great concern for public health and an increasing risk for hospital-acquired infections. The ongoing increase in antibiotic-resistant bacterial strains highlights the urgent need to find new effective alternatives to antibiotics. Hyaluronic acid (HA) is a valuable polymer in biomedical applications, partly due to its bactericidal effects on different platforms such as contact lenses, cleaning solutions, wound dressings, cosmetic formulations, etc. Because the pure form of HA is rapidly hydrolyzed, nanotechnology-based approaches have been investigated to improve its clinical utility. Moreover, a combination of HA with other bactericidal molecules could improve the antibacterial effects on drug-resistant bacterial strains, and improve the management of hard-to-heal wound infections. This review summarizes the structure, production, and properties of HA, and its various platforms as a carrier in drug delivery. Herein, we discuss recent works on numerous types of HA-based nanoparticles to overcome the limitations of traditional antibiotics in the treatment of bacterial infections. Advances in the fabrication of controlled release of antimicrobial agents from HA-based nanosystems can allow the complete eradication of pathogenic microorganisms.
医疗器械的细菌污染是公共卫生的重大关切问题，也是医院获得性感染风险不断增加的因素。抗生素耐药菌株的持续增加凸显了寻找新型有效抗生素替代品的迫切需求。透明质酸（HA）在生物医学应用中是一种有价值的聚合物，部分原因在于其对隐形眼镜、清洁溶液、伤口敷料、化妆品配方等不同平台具有杀菌作用。由于HA的纯形式会迅速水解，因此已对基于纳米技术的方法进行了研究，以提高其临床实用性。此外，HA与其他杀菌分子的组合可增强对耐药菌株的抗菌效果，并改善难愈合伤口感染的处理。本综述总结了HA的结构、生产和性质，以及其作为药物递送载体的各种平台。在此，我们讨论了近期关于多种基于HA的纳米颗粒的研究工作，以克服传统抗生素在治疗细菌感染方面的局限性。基于HA的纳米系统在抗菌剂控释制备方面的进展能够实现对致病微生物的彻底根除。
