板层黄斑裂孔与视网膜内界膜黄斑裂孔对比研究。

Comparison of vitreoretinal disorders in fellow eyes of lamellar macular holes versus epiretinal membrane foveoschisis.

机构信息

Retina Division, Stein Eye Institute, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA, USA.

Ophthalmology Department, Université de Paris, AP-HP, Hôpital Lariboisière, F-75010, Paris, France.

出版信息

Graefes Arch Clin Exp Ophthalmol. 2020 Dec;258(12):2611-2619. doi: 10.1007/s00417-020-04950-y. Epub 2020 Oct 3.

DOI:10.1007/s00417-020-04950-y

PMID:33009974

Abstract

PURPOSE

To evaluate and compare the rate and characteristics of vitreoretinal disorders in fellow eyes of lamellar macular holes (LMH) versus epiretinal membrane foveoschisis (ERMF).

METHODS

Included patients in this retrospective study were divided into two groups based on spectral-domain optical coherence tomography (SD-OCT) features of their primary eye: LMH (group A) and ERMF (group B).

RESULTS

Ninety-four patients were enrolled: 59 (62.8%) in group A and 35 (37.2%) in group B. Fellow eyes in group A had a higher rate of retinal detachment (8/59 [13.6%] vs. 0/35 [0%], P = 0.024), and full-thickness macular hole (FTMH) (11/59 [18.6%] vs. 2/35 [5.7%], P = 0.079), compared with fellow eyes in group B. In group A, 4/59 patients (6.8%) showed a bilateral LMH while none from group B had a LMH in their fellow eye (0/35 [0%]), P = 0.293. Additionally, epiretinal proliferation was noted in 30/59 (50.8%) fellow eyes in group A versus 3/35 (8.6%) fellow eyes in group B, P < 0.001. Longitudinal data were available for 80/94 patients. Over a mean follow-up of 37.4 ± 29.9 months, 1/48 (2.1%) fellow eyes from group A developed a FTMH and 2/48 (4.2%) developed a LMH, while no FTMH or LMH occurred in fellow eyes of group B.

CONCLUSIONS

Fellow eyes of LMH showed a high rate of macular and peripheral vitreoretinal disorders. In addition, epiretinal proliferation was detected in a higher number of fellow eyes of LMH versus ERMF. These findings suggest a bilateral process in eyes of patients with LMH.

摘要

目的

评估并比较板层黄斑裂孔（LMH）和视网膜内界膜黄斑裂孔（ERM）对患眼玻璃体积视网膜病变的发生率和特征。

方法

本回顾性研究根据原发性眼的谱域光学相干断层扫描（SD-OCT）特征将患者分为两组：LMH（A 组）和 ERM（B 组）。

结果

共纳入 94 例患者：A 组 59 例（62.8%），B 组 35 例（37.2%）。A 组患眼视网膜脱离的发生率较高（8/59 [13.6%] vs. 0/35 [0%]，P=0.024），全层黄斑裂孔（FTMH）的发生率也较高（11/59 [18.6%] vs. 2/35 [5.7%]，P=0.079）。与 B 组相比，A 组 4/59 例（6.8%）患者双侧 LMH，而 B 组无患眼 LMH（0/35 [0%]），P=0.293。此外，A 组 59 例患眼中有 30 例（50.8%）存在视网膜内增殖，而 B 组 35 例患眼中有 3 例（8.6%），P<0.001。94 例患者中有 80 例可获得纵向数据。在平均 37.4±29.9 个月的随访中，A 组的 48 例患眼中有 1 例（2.1%）发生 FTMH，2 例（4.2%）发生 LMH，而 B 组的 48 例患眼中无 FTMH 或 LMH 发生。