Compera Denise, Schumann Ricarda G, Cereda Matteo G, Acquistapace Alessandra, Lita Viviane, Priglinger Siegfried G, Staurenghi Giovanni, Bottoni Ferdinando
Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
Eye Clinic, Department of Biomedical and Clinical Science 'Luigi Sacco', Sacco Hospital, University of Milan, Via G.B. Grassi 74, Milan, Italy.
Br J Ophthalmol. 2018 Jan;102(1):84-90. doi: 10.1136/bjophthalmol-2016-310128. Epub 2017 May 25.
To report on progression of lamellar hole-associated epiretinal proliferation (LHEP) in eyes with lamellar macular holes (LMH) using spectral-domain optical coherence tomography (SD-OCT), and to correlate with intraretinal changes and visual function.
From a retrospectively reviewed series of 167 eyes with non-full-thickness macular holes, we exclusively included a subgroup of 34 eyes with LMH and LHEP by SD-OCT evaluation. In these eyes, area of LHEP, intraretinal changes of defect diameter, central retinal thickness, defects of the ellipsoid zone and occurrence of a contractive epiretinal membrane were analysed. Additionally, clinical data were documented.
Area of LHEP significantly increased during a mean follow-up period of 40.5 months (median 52 months). Analysing intraretinal changes, a significant enlargement of minimum and maximum horizontal lamellar hole diameter was found that correlated with the area of LHEP. Defects of the ellipsoid zone were seen in 65% of the eyes at baseline and in 85% at the end of follow-up. Increase of maximum horizontal hole diameter and ellipsoid zone defects correlated with a decline of visual acuity. Fifty per cent of patients with LMH and LHEP also demonstrated extrafoveal typical contractive epiretinal membranes with retinal folds.
Long-term follow-up revealed an increase of the area of LHEP in eyes with LMH that correlated with the enlargement of lamellar hole diameter and ellipsoid zone defects. Our data delineate the progression of intraretinal changes in association with a decline of visual function in this subgroup of LMH eyes.
使用光谱域光学相干断层扫描（SD - OCT）报告伴有黄斑板层裂孔（LMH）的眼中板层孔相关视网膜前增殖（LHEP）的进展情况，并将其与视网膜内变化和视觉功能相关联。
在回顾性分析的167例非全层黄斑裂孔眼中，我们通过SD - OCT评估专门纳入了34例伴有LMH和LHEP的亚组。对这些眼睛分析LHEP的面积、视网膜内缺陷直径的变化、中心视网膜厚度、椭圆体带的缺陷以及收缩性视网膜前膜的发生情况。此外，记录临床数据。
在平均40.5个月（中位数52个月）的随访期内，LHEP的面积显著增加。分析视网膜内变化发现，最小和最大水平板层裂孔直径显著增大，且与LHEP的面积相关。在基线时，65%的眼睛可见椭圆体带缺陷，随访结束时为85%。最大水平裂孔直径的增加和椭圆体带缺陷与视力下降相关。50%伴有LMH和LHEP的患者还表现出黄斑外典型的收缩性视网膜前膜并伴有视网膜皱褶。
长期随访显示，伴有LMH的眼中LHEP面积增加，这与板层裂孔直径增大和椭圆体带缺陷相关。我们的数据描绘了该亚组LMH眼中视网膜内变化与视觉功能下降相关的进展情况。
