Baandrup Louise, Faber Mette T, Aalborg Gitte L, Kjaer Susanne K
Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Statistics and Pharmacoepidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark.
Acta Obstet Gynecol Scand. 2021 Mar;100(3):436-443. doi: 10.1111/aogs.14013. Epub 2020 Oct 21.
After some decades with an increasing incidence of borderline ovarian tumors, more recent studies have observed that the incidence rate seems to be leveling off or declining. In this study, we describe the incidence of borderline ovarian tumors in Denmark 1997-2018 by histology, age at diagnosis and educational level.
All borderline ovarian tumors registered in the Danish Pathology Registry during 1997-2018 were identified and individual-level educational information was retrieved from nationwide registers. Age-standardized incidence rates were estimated according to histology, age at diagnosis and educational level. To investigate incidence trends over time, the average annual percentage change and corresponding 95% confidence intervals (CIs) were estimated using Poisson regression.
We identified 3927 women with borderline ovarian tumors during the study period, of which 1997 (50.9%) were serous and 1743 (44.4%) were mucinous. The age-standardized incidence rate of serous borderline ovarian tumors did not change significantly over calendar time (average annual percentage change = -0.13, 95% confidence interval [CI] -1.13 to 0.88). For mucinous tumors, the age-standardized incidence rate was also relatively stable during the first half of the study period, followed by a decrease from 2.56 to 1.25 per 100 000 person-years between 2007-2011 and 2017-2018. Over the entire study period, the incidence rate of mucinous borderline tumors declined on average by 2.91% (95% CI -4.24 to -1.51) per year. The incidence of both types of borderline ovarian tumors seemed to be highest among women with a low educational level. Over calendar time, the incidence of mucinous tumors decreased in all educational groups, whereas the incidence of serous tumors decreased exclusively in women with a high educational level. Time trends did not differ markedly by age at diagnosis.
In Denmark, the incidence of serous borderline ovarian tumors was stable during 1997-2018, whereas the incidence of mucinous borderline ovarian tumors decreased. The incidence rates of both types of borderline ovarian tumors tended to be highest among women with a low educational level throughout the study period.
在交界性卵巢肿瘤发病率上升数十年后，最近的研究发现发病率似乎趋于平稳或下降。在本研究中，我们按组织学类型、诊断时年龄和教育程度描述了1997年至2018年丹麦交界性卵巢肿瘤的发病率。
确定1997年至2018年丹麦病理登记处登记的所有交界性卵巢肿瘤，并从全国登记处获取个人层面的教育信息。根据组织学类型、诊断时年龄和教育程度估计年龄标准化发病率。为了调查发病率随时间的趋势，使用泊松回归估计平均年度百分比变化及相应的95%置信区间（CI）。
在研究期间，我们确定了3927例交界性卵巢肿瘤女性患者，其中1997例（50.9%）为浆液性，1743例（44.4%）为黏液性。浆液性交界性卵巢肿瘤的年龄标准化发病率在日历时间内没有显著变化（平均年度百分比变化=-0.13，95%置信区间[CI]-1.13至0.88）。对于黏液性肿瘤，在研究期的前半段，年龄标准化发病率也相对稳定，随后在2007 - 2011年至2017 - 2018年期间从每10万人年2.56降至1.25。在整个研究期间，黏液性交界性肿瘤的发病率平均每年下降2.91%（95% CI -4.24至-1.51）。两种类型的交界性卵巢肿瘤发病率在教育程度低的女性中似乎最高。在日历时间内，黏液性肿瘤的发病率在所有教育组中均下降，而浆液性肿瘤的发病率仅在高教育程度女性中下降。发病时间趋势在诊断时年龄方面没有显著差异。
在丹麦，1997年至2018年期间浆液性交界性卵巢肿瘤的发病率稳定，而黏液性交界性卵巢肿瘤的发病率下降。在整个研究期间，两种类型的交界性卵巢肿瘤发病率在教育程度低的女性中往往最高。
