State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Panjin, Liaoning, People's Republic of China.
School of Life Science and Medicine, Dalian University of Technology, Panjin, Liaoning, People's Republic of China.
IET Nanobiotechnol. 2020 Sep;14(7):595-601. doi: 10.1049/iet-nbt.2020.0076.
Metal-organic frameworks (MOFs) as drug carriers have many advantages than traditional drug carriers and have received extensive attention from researchers. However, how to regulate the microstructure of MOFs to improve the efficiency of drug delivery and sustained release behaviour is still a big problem for the clinical application. Herein, the authors synthesise surfactant-modified ZIF-8 nanoparticles with different microstructures by using different types of surfactants to modify ZIF-8. The surfactant-modified ZIF-8 nanoparticles have the larger specific surface area and total micropore volumes than the original ZIF-8, which enables doxorubicin (DOX) to be more effectively loaded on the drug carriers and achieve controlled drug sustained release. Excellent degradation performance of ZIF-8 nanoparticles facilitates the metabolism of drug carriers. The formulation was evaluated for cytotoxicity, cellular uptake and intracellular location in the A549 human non-small-cell lung cancer cell line. ZIF-8/DOX nano drugs exhibit higher cytotoxicity towards cells in comparison with free DOX, suggesting the potential application in nano drugs to cancer chemotherapy.
金属-有机骨架（MOFs）作为药物载体比传统药物载体具有许多优势，受到研究人员的广泛关注。然而，如何调节 MOFs 的微观结构以提高药物输送效率和持续释放行为仍然是临床应用的一个大问题。在此，作者通过使用不同类型的表面活性剂来修饰 ZIF-8，合成了具有不同微观结构的表面活性剂修饰的 ZIF-8 纳米粒子。与原始 ZIF-8 相比，表面活性剂修饰的 ZIF-8 纳米粒子具有更大的比表面积和总微孔体积，这使得阿霉素（DOX）能够更有效地负载在药物载体上，并实现药物的控制释放。ZIF-8 纳米粒子具有优异的降解性能，有利于药物载体的新陈代谢。在 A549 人非小细胞肺癌细胞系中，对该制剂的细胞毒性、细胞摄取和细胞内定位进行了评价。与游离 DOX 相比，ZIF-8/DOX 纳米药物对细胞表现出更高的细胞毒性，这表明其在癌症化疗中的纳米药物应用潜力。
