Yang Xue, Li Liling, He Dinggeng, Hai Luo, Tang Jinlu, Li Haifeng, He Xiaoxiao, Wang Kemin
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, P. R. China.
J Mater Chem B. 2017 Jun 28;5(24):4648-4659. doi: 10.1039/c7tb00715a. Epub 2017 May 23.
Here, we report a novel metal-organic framework-based nanocomposite with encapsulated Pd@Au nanoparticles and doxorubicin (DOX) for pH- and NIR-triggered synergistic chemo-photothermal treatment of cancer cells. In this work, Pd nanoparticles, which have uniform size and dispersibility, were first synthesized and used as a template to direct the covering of Au nanosheets. The obtained Au coated Pd (Pd@Au) nanoparticles have excellent dispersibility and photothermal conversion ability, which makes them a good photothermal nanomaterial. Subsequently, an acid-degradable metal-organic framework of ZIF-8 was employed to synchronously encapsulate Pd@Au nanoparticles and DOX to get a metal-organic framework-based nanocomposite (DOX/Pd@Au@ZIF-8). Under acid conditions (e.g. pH ∼5.0 in a lysosome), the ZIF-8 framework of the DOX/Pd@Au@ZIF-8 nanocomposite could be degraded, resulting in the release of encapsulated DOX. Moreover, the present Pd@Au nanoparticles can effectively convert NIR laser light (780 nm, 2.1 W cm) into heat, not only further promoting the release of DOX, but also realizing the synergistic chemo-photothermal treatment of cancer cells. The in vitro experiments showed that this nanocomposite system has an excellent synergistic treatment effect on SMMC-7721 cells, even at low concentrations (e.g. 20 μg mL). With the properties of synergistic chemo-photothermal treatment, we hope that such a nanocomposite system of DOX/Pd@Au@ZIF-8 could open the door to designing a significant multifunctional system for diverse applications in cancer treatment.
在此，我们报道了一种新型的基于金属有机框架的纳米复合材料，其包裹有钯@金纳米颗粒和阿霉素（DOX），用于对癌细胞进行pH和近红外触发的协同化学-光热治疗。在这项工作中，首先合成了尺寸均匀且分散性良好的钯纳米颗粒，并将其用作模板来引导金纳米片的包覆。所获得的金包覆钯（Pd@Au）纳米颗粒具有优异的分散性和光热转换能力，这使其成为一种良好的光热纳米材料。随后，采用可酸降解的ZIF-8金属有机框架来同步包裹Pd@Au纳米颗粒和DOX，从而得到一种基于金属有机框架的纳米复合材料（DOX/Pd@Au@ZIF-8）。在酸性条件下（例如溶酶体中的pH约为5.0），DOX/Pd@Au@ZIF-8纳米复合材料的ZIF-8框架会降解，导致包裹的DOX释放。此外，目前的Pd@Au纳米颗粒能够有效地将近红外激光（780 nm，2.1 W/cm）转化为热量，不仅进一步促进DOX的释放，还能实现对癌细胞的协同化学-光热治疗。体外实验表明，即使在低浓度（例如20 μg/mL）下，这种纳米复合体系对SMMC-7721细胞也具有优异的协同治疗效果。凭借协同化学-光热治疗的特性，我们希望这种DOX/Pd@Au@ZIF-8纳米复合体系能够为设计用于癌症治疗中多种应用的重要多功能体系打开大门。
