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用于靶向药物递送和磁共振成像的透明质酸共轭金属有机框架的制备

Fabrication of a hyaluronic acid conjugated metal organic framework for targeted drug delivery and magnetic resonance imaging.

作者信息

Shu Fangpeng, Lv Daojun, Song Xian-Lu, Huang Bin, Wang Chong, Yu Yuzhong, Zhao Shan-Chao

机构信息

Department of Urology, Nanfang Hospital, Southern Medical University Guangzhou 510515 China

Department of Radiation Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University Guangzhou 510095 China.

出版信息

RSC Adv. 2018 Feb 9;8(12):6581-6589. doi: 10.1039/c7ra12969f. eCollection 2018 Feb 6.

DOI:10.1039/c7ra12969f
PMID:35540394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9078328/
Abstract

Since metal organic frameworks (MOF) have exhibited fascinating potential in biomedical applications, it is worthwhile to construct a MOF-based multifunctional drug delivery system. In the present study, the anticancer drug doxorubicin (DOX) was loaded into zeolitic imidazolate framework-8 (ZIF-8) a one-pot process. The formed DOX@ZIF-8 was then coated with polydopamine, successively chelated with Fe and conjugated with hyaluronic acid (HA), finally resulting in a multifunctional ZIF-8 nanocarrier. The characterization results confirmed the successful formation of the hybrid nanocarrier. pH-responsive drug release of DOX was observed due to the innate pH-dependent stability of ZIF-8. Importantly, the flow cytometry and confocal laser scanning microscope results both verified the targeting ability of DOX@ZIF-HA toward prostate cancer PC-3 cells. The improved therapeutic efficacy of DOX@ZIF-HA when compared to the inhibited group was also demonstrated. Furthermore, the chelation of Fe by PDA makes the prepared DOX@ZIF-HA a good contrast agent for magnetic resonance (MR) imaging. Hence, we hope the constructed ZIF-8 based multifunctional nanocarrier could be a candidate for cancer theranostics.

摘要

由于金属有机框架（MOF）在生物医学应用中展现出了迷人的潜力，因此构建基于MOF的多功能药物递送系统是值得的。在本研究中，抗癌药物阿霉素（DOX）通过一锅法被载入沸石咪唑酯骨架-8（ZIF-8）中。然后将形成的DOX@ZIF-8用聚多巴胺包被，依次与铁螯合并与透明质酸（HA）偶联，最终得到一种多功能ZIF-8纳米载体。表征结果证实了杂化纳米载体的成功形成。由于ZIF-8固有的pH依赖性稳定性，观察到了DOX的pH响应性药物释放。重要的是，流式细胞术和共聚焦激光扫描显微镜结果均证实了DOX@ZIF-HA对前列腺癌PC-3细胞的靶向能力。与抑制组相比，DOX@ZIF-HA的治疗效果也得到了改善。此外，聚多巴胺对铁的螯合使得制备的DOX@ZIF-HA成为一种用于磁共振（MR）成像的良好造影剂。因此，我们希望构建的基于ZIF-8的多功能纳米载体能够成为癌症诊疗的候选者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/041f4b3f678c/c7ra12969f-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/3fdbdab43e29/c7ra12969f-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/44c41974b0f5/c7ra12969f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/b6c2f624f5a2/c7ra12969f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/e93be6ce0f01/c7ra12969f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/a48177e183f8/c7ra12969f-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/deab76fe3094/c7ra12969f-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/36218987b299/c7ra12969f-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/041f4b3f678c/c7ra12969f-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/3fdbdab43e29/c7ra12969f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/86be734c1055/c7ra12969f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/44c41974b0f5/c7ra12969f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/b6c2f624f5a2/c7ra12969f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/e93be6ce0f01/c7ra12969f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/a48177e183f8/c7ra12969f-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/deab76fe3094/c7ra12969f-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/36218987b299/c7ra12969f-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad6/9078328/041f4b3f678c/c7ra12969f-f9.jpg

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