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接收体形状和体积对通过扩散进行分子通信的阿尔茨海默病的影响。

Effect of receiver shape and volume on the Alzheimer disease for molecular communication via diffusion.

机构信息

Department of Electrical Electronics Engineering, Inonu University, Engineering faculty, Malatya, Turkey.

Computer Networks Research Laboratory (NETLAB), Department of Computer Engineering, Bogazici University, Istanbul, Turkey.

出版信息

IET Nanobiotechnol. 2020 Sep;14(7):602-608. doi: 10.1049/iet-nbt.2019.0300.

Abstract

Nano-devices are featured to communicate via molecular interaction, the so-called molecular communication (MC). In MC systems, the information is carried by molecules where the amount of molecules constitutes the level of the signal. In this study, an MC-based system was analysed with different receiver topology and related parameters, such as size, shape, and orientation of receptors on the receiver. Also in the concept of nano-medicine, the effect of amyloid-beta ([inline-formula removed]), which is believed as the main cause of Alzheimer disease, on the successful reception ratio of molecules with the proposed receiver models was investigated. It was demonstrated that the cubic receiver model is superior to sphere one in terms of the correct reception ratio of the molecular signal. A cubic model where its edge (not rotated around the centre) is placed across the transmitter demonstrated a better performance in reducing the effect of [inline-formula removed] as compared to the sphere model while a cubic model where its corner (rotated around the centre) is placed across the transmitter demonstrated a worse performance than the spherical model. From this expression, it may be concluded that with the adjustment of topological system parameters the probability of successful reception ratio in MC may be possible.

摘要

纳米器件的特点是通过分子相互作用进行通信,即所谓的分子通信 (MC)。在 MC 系统中,信息由分子携带,而分子的数量构成了信号的电平。在这项研究中,分析了基于 MC 的系统,研究了不同的接收器拓扑结构和相关参数,如接收器上受体的大小、形状和方向。在纳米医学的概念中,还研究了淀粉样蛋白-β ([inline-formula removed]) 的作用,它被认为是阿尔茨海默病的主要原因,对所提出的接收器模型中分子的成功接收比率的影响。结果表明,在分子信号的正确接收比率方面,立方接收器模型优于球形模型。与球形模型相比,当边缘(不绕中心旋转)穿过发射器时,立方模型在减少 [inline-formula removed] 的影响方面表现出更好的性能,而当角(绕中心旋转)穿过发射器时,立方模型的性能比球形模型差。由此可以得出结论,通过调整拓扑系统参数,在 MC 中成功接收比率的概率是可能的。

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