肽修饰的脂质体作为癌症治疗的治疗和诊断工具。
Peptide-functionalized liposomes as therapeutic and diagnostic tools for cancer treatment.
机构信息
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
出版信息
J Control Release. 2021 Jan 10;329:624-644. doi: 10.1016/j.jconrel.2020.09.055. Epub 2020 Oct 1.
Abstract
Clinically efficacious medication in anticancer therapy has been successfully designed with liposome-based nanomedicine. The liposomal formulation in cancer drug delivery can be facilitated with a functionalized peptide that mediates the specific drug delivery opportunities with increased drug penetrability, specific accumulation in the targeted site, and enhanced therapeutic efficacy. This review aims to focus on recent advances in peptide-functionalized liposomal formulation techniques in cancer diagnosis and treatment regarding recently published literature. It also will highlight different aspects of novel liposomal formulation techniques that incorporate surface functionalization with peptides for better anticancer effect and current challenges in peptide-functionalized liposomal drug formulation.
摘要
基于脂质体的纳米医学成功设计了具有临床疗效的抗癌治疗药物。通过功能化肽可以促进脂质体在癌症药物递送中的应用，从而增加药物穿透性、在靶部位的特异性积累和增强治疗效果，介导特定的药物递送机会。本综述旨在关注最近在癌症诊断和治疗方面关于已发表文献的肽功能化脂质体制剂技术的进展。它还将重点介绍新型脂质体制剂技术的不同方面，包括通过肽进行表面功能化以获得更好的抗癌效果，以及肽功能化脂质体药物制剂目前面临的挑战。
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2
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