Conway K, Wang X W, Xu L S, Costa M
Carcinogenesis. 1987 Aug;8(8):1115-21. doi: 10.1093/carcin/8.8.1115.
Raising the extracellular level of magnesium ions inhibited nickel-induced DNA strand breaks, DNA-protein crosslinks, sister chromatid exchanges, chromosomal aberrations and cell transformation. Carcinogenic nickel ions preferentially damaged centromeres and other heterochromatic regions of Chinese hamster ovary cell chromosomes. Elevation of extracellular magnesium levels prevented the effects of nickel on heterochromatin and inhibited cell transformation, but did not substantially reduce the DNA damage induced by nickel in euchromatic regions. This study suggests that heterochromatic DNA damage may be important to the nickel-induced neoplastic transformation process.
提高细胞外镁离子水平可抑制镍诱导的DNA链断裂、DNA-蛋白质交联、姐妹染色单体交换、染色体畸变以及细胞转化。致癌镍离子优先损伤中国仓鼠卵巢细胞染色体的着丝粒和其他异染色质区域。细胞外镁水平的升高可防止镍对异染色质的影响并抑制细胞转化，但并未显著降低镍在常染色质区域诱导的DNA损伤。这项研究表明，异染色质DNA损伤可能对镍诱导的肿瘤转化过程至关重要。
