Clinical Microbiology Laboratory, Tel-Aviv Sourasky Medical Center, 6 Weizmann Street, Tel-Aviv 6423906 Israel; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Division of Internal Medicine, Shaare Zedek Medical Center, 12 Shmuel Bait Street, Jerusalem 9103102, Israel.
Infect Dis Clin North Am. 2020 Dec;34(4):677-708. doi: 10.1016/j.idc.2020.06.003. Epub 2020 Sep 30.
Antimicrobial resistance is a common iatrogenic complication of modern life and medical care. One of the most demonstrative examples is the exponential increase in the incidence of extended-spectrum β-lactamases (ESBLs) production among Enterobacteriaceae, that is, the most common human pathogens outside of the hospital setting. Infections resulting from ESBL-producing bacteria are associated with devastating outcomes, now affecting even previously healthy individuals. This poses an enormous burden and threat to public health. This article aims to narrate the evolving epidemiology of ESBL infections and highlights current challenges in terms of management and prevention of these common infections.
抗微生物药物耐药性是现代生活和医疗的常见医源性并发症。最具代表性的例子之一是肠杆菌科中超广谱β-内酰胺酶（ESBL）产生的发病率呈指数级增长，即在医院环境之外最常见的人类病原体。由产 ESBL 细菌引起的感染与破坏性结果相关，现在甚至影响到以前健康的个体。这对公共卫生构成了巨大的负担和威胁。本文旨在叙述 ESBL 感染的不断变化的流行病学，并强调在这些常见感染的管理和预防方面当前面临的挑战。
