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在 Wurster 包衣机中进行丸芯包衣的模拟。

Simulation of pellet coating in Wurster coaters.

机构信息

Center of Engineering and Multiscale Modeling of Fluid Flow (CEMF), Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnique), PO Box: 15875-4413, Hafez 424, Tehran, Iran.

出版信息

Int J Pharm. 2020 Nov 30;590:119931. doi: 10.1016/j.ijpharm.2020.119931. Epub 2020 Oct 1.

Abstract

A combination of computational fluid dynamics (CFD), discrete element method (DEM), and discrete droplet method (DDM), i.e., a CFD-DEM-DDM model, was developed to simulate coating of pellets in a Wurster coater. The model equations were implemented in parallel using an approach that uses the computational resources of both CPU and GPU. Effects of the gas flow pattern, inlet gas temperature, partition gap, and spray characteristics were studied on the process. Decreasing the peripheral gas velocity, increasing the central jet velocity, and reducing the partition gap caused more uniform distributions of the circulation time and draft tube time, while the inlet gas temperature had negligible effect on them. Very high jet velocity caused a wider distribution of the circulation time. The dynamics of the spray and its interaction with pellets had significant effects on the coating mass distribution. Widening the spray angle while maintaining the droplet size constant caused the most uniform coating mass distribution and the highest deposition rate. Heat and mass transfer conditions as well as the deposition pattern changed the distributions of the solvent content and temperature of the pellets.

摘要

采用计算流体动力学(CFD)、离散单元法(DEM)和离散液滴法(DDM)相结合的方法,即 CFD-DEM-DDM 模型,对 Wurster 包衣机中丸粒的包衣过程进行模拟。采用一种同时利用 CPU 和 GPU 计算资源的方法,实现了模型方程的并行化。研究了气流模式、进口气体温度、分隔间隙和喷雾特性对该过程的影响。降低周边气体速度、增加中心射流速度和减小分隔间隙会导致循环时间和导流管时间的分布更加均匀,而进口气体温度对其影响可以忽略不计。非常高的射流速度会导致循环时间的分布范围变宽。喷雾的动力学及其与丸粒的相互作用对涂层质量分布有显著影响。在保持液滴尺寸不变的情况下,扩大喷雾角度会导致最均匀的涂层质量分布和最高的沉积速率。传热传质条件以及沉积模式改变了丸粒的溶剂含量和温度分布。

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