Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil; Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Placenta. 2020 Nov;101:204-207. doi: 10.1016/j.placenta.2020.09.062. Epub 2020 Sep 28.
To investigate the role of TYRO3, AXL and TIM1 receptors in the Zika virus (ZIKV) cycle, we determined their mRNA expression in different placental sites of ZIKV infected tissue during pregnancy. Unexpectedly, the ZIKV infection was not related with mRNA upregulation of these receptors or changes in expression of type I and III interferons in different placental sites. Instead, a decrease of TYRO3 mRNA expression was observed in positive sites of ZIKV positive placentas in comparison to negative sites. The basis of this downregulation can help to understand how ZIKV persists in placental tissue during pregnancy.
为了研究 TYRO3、AXL 和 TIM1 受体在 Zika 病毒（ZIKV）周期中的作用，我们在妊娠期间确定了它们在不同胎盘组织中 ZIKV 感染组织中的 mRNA 表达。出乎意料的是，ZIKV 感染与这些受体的 mRNA 上调无关，也与不同胎盘部位的 I 型和 III 型干扰素的表达变化无关。相反，与 ZIKV 阴性胎盘的阳性部位相比，ZIKV 阳性胎盘的 TYRO3 mRNA 表达减少。这种下调的基础有助于了解 ZIKV 如何在妊娠期间在胎盘组织中持续存在。
