Platt D R
Clin Lab Med. 1987 Jun;7(2):289-99.
Individualizing drug dosage regimens is a common application of therapeutic drug monitoring. For drugs with a narrow therapeutic index or variable pharmacokinetic parameters, pharmacokinetic-based dosing can be useful. Pharmacokinetic methods that can aid the clinician in targeting for desired drug serum concentrations have been developed and clinically evaluated. These methods range from single nomograms or pharmacokinetic equations in which no serum concentrations are necessary to more complex techniques requiring serum concentration data and computer support. The most recently developed technique, Bayesian forecasting, may allow for more precise dosage individualization.
个体化给药方案是治疗药物监测的常见应用。对于治疗指数窄或药代动力学参数可变的药物，基于药代动力学的给药可能会有所帮助。已经开发并进行了临床评估一些药代动力学方法，这些方法可以帮助临床医生确定所需的药物血清浓度。这些方法从不需要血清浓度的单一诺模图或药代动力学方程到需要血清浓度数据和计算机支持的更复杂技术不等。最新开发的技术——贝叶斯预测，可能会实现更精确的个体化给药。
